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AMPK activator C 2

" in MedChemExpress (MCE) Product Catalog:

By Targets:	AMPK (4) Apoptosis (1) Autophagy (2) Bacterial (1) Endogenous Metabolite (1) Isotope-Labeled Compounds (3) Mitophagy (2) mTOR (1) Parasite (1) PPAR (1) YAP (1)
By Research Areas:	Cancer (1) Cardiovascular Disease (1) Infection (1) Metabolic Disease (2) Neurological Disease (2)

Inhibitors & Agonists

Isotope-Labeled Compounds

Targets Recommended: AMPK

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-130155

AMPK activator C2	AMPK	Neurological Disease
AMPK activator C2 is a potent allosteric *AMPK* activator that is promising for research of epilepsy and convulsions .

HY-13417S

AICAR-13C2,15N Acadesine-¹³C₂,¹⁵N; AICA Riboside-¹³C₂,¹⁵N	Isotope-Labeled Compounds Endogenous Metabolite YAP AMPK Mitophagy Autophagy	Others
AICAR- ¹³C₂, ¹⁵N (Acadesine- ¹³C₂, ¹⁵N; AICA Riboside- ¹³C₂, ¹⁵N) is the ¹³C and ¹⁵N labeled AICAR (HY-13417) . AICAR (Acadesine) is an adenosine analog and a *AMPK* activator. AICAR regulates the glucose and lipid metabolism, and inhibits proinflammatory cytokines and iNOS production. AICAR is also an autophagy, YAP and mitophagy inhibitor .

HY-B0627S1

Metformin-13C2 hydrochloride 1,1-Dimethylbiguanide-¹³C₂ hydrochloride	Isotope-Labeled Compounds AMPK Autophagy Mitophagy Apoptosis mTOR	Cardiovascular Disease Metabolic Disease Cancer
Metformin- ¹³C₂ (1,1-Dimethylbiguanide- ¹³C₂) hydrochloride is the ¹³C-labeled Metformin hydrochloride (HY-17471A). Metformin hydrochloride inhibits the mitochondrial respiratory chain in the liver, leading to AMPK activation and enhancing insulin sensitivity, and can be used in the study of type 2 diabetes. Metformin hydrochloride also inhibits liver oxidative stress, nitrosative stress, inflammation, and apoptosis caused by liver ischemia/reperfusion injury. In addition, metformin hydrochloride regulates the expression of autophagy-related proteins by activating AMPK and inhibiting the mTOR signaling pathway, thereby inducing tumor cell autophagy and inhibiting the growth of renal cell carcinoma in vitro and in vivo .

HY-N0059S2

D-arabinose-13C-2	Isotope-Labeled Compounds Parasite Bacterial AMPK PPAR	Infection Neurological Disease Metabolic Disease
D-Arabinose- ¹³C-2 is the ¹³C labeled D-Arabinose (HY-N0059). D-Arabinose is is an orally active antidepressant and a growth inhibitor of C. elegans (IC₅₀ is 7.5 mM). D-Arabinose can penetrate the blood-brain barrier, selectively interfere with the metabolism of D-ribose and D-fructose, and inhibit the growth of nematodes. D-Arabinose can also inhibit the synthesis of cell biofilm and exert antibacterial activity. D-Arabinose activates the ACSS2-PPARγ/TFEB-CRTC1 axis through the lysosomal *AXIN-LKB1-AMPK* pathway, inducing CRTC1 transcription, exerts antidepressant-like activity. D-Arabinose is the ring-opened form of the aldopentose D-?Arabinose (HY-N7082) .

Cat. No.	Product Name	Chemical Structure

HY-13417S

AICAR-13C2,15N
AICAR- ¹³C₂, ¹⁵N (Acadesine- ¹³C₂, ¹⁵N; AICA Riboside- ¹³C₂, ¹⁵N) is the ¹³C and ¹⁵N labeled AICAR (HY-13417) . AICAR (Acadesine) is an adenosine analog and a *AMPK* activator. AICAR regulates the glucose and lipid metabolism, and inhibits proinflammatory cytokines and iNOS production. AICAR is also an autophagy, YAP and mitophagy inhibitor .

HY-B0627S1

Metformin-13C2 hydrochloride
Metformin- ¹³C₂ (1,1-Dimethylbiguanide- ¹³C₂) hydrochloride is the ¹³C-labeled Metformin hydrochloride (HY-17471A). Metformin hydrochloride inhibits the mitochondrial respiratory chain in the liver, leading to AMPK activation and enhancing insulin sensitivity, and can be used in the study of type 2 diabetes. Metformin hydrochloride also inhibits liver oxidative stress, nitrosative stress, inflammation, and apoptosis caused by liver ischemia/reperfusion injury. In addition, metformin hydrochloride regulates the expression of autophagy-related proteins by activating AMPK and inhibiting the mTOR signaling pathway, thereby inducing tumor cell autophagy and inhibiting the growth of renal cell carcinoma in vitro and in vivo .

Metformin-13C2 hydrochloride

Metformin- ¹³C₂ (1,1-Dimethylbiguanide- ¹³C₂) hydrochloride is the ¹³C-labeled Metformin hydrochloride (HY-17471A). Metformin hydrochloride inhibits the mitochondrial respiratory chain in the liver, leading to AMPK activation and enhancing insulin sensitivity, and can be used in the study of type 2 diabetes. Metformin hydrochloride also inhibits liver oxidative stress, nitrosative stress, inflammation, and apoptosis caused by liver ischemia/reperfusion injury. In addition, metformin hydrochloride regulates the expression of autophagy-related proteins by activating AMPK and inhibiting the mTOR signaling pathway, thereby inducing tumor cell autophagy and inhibiting the growth of renal cell carcinoma in vitro and in vivo .

HY-N0059S2

D-arabinose-13C-2
D-Arabinose- ¹³C-2 is the ¹³C labeled D-Arabinose (HY-N0059). D-Arabinose is is an orally active antidepressant and a growth inhibitor of C. elegans (IC₅₀ is 7.5 mM). D-Arabinose can penetrate the blood-brain barrier, selectively interfere with the metabolism of D-ribose and D-fructose, and inhibit the growth of nematodes. D-Arabinose can also inhibit the synthesis of cell biofilm and exert antibacterial activity. D-Arabinose activates the ACSS2-PPARγ/TFEB-CRTC1 axis through the lysosomal *AXIN-LKB1-AMPK* pathway, inducing CRTC1 transcription, exerts antidepressant-like activity. D-Arabinose is the ring-opened form of the aldopentose D-?Arabinose (HY-N7082) .

D-arabinose-13C-2

D-Arabinose- ¹³C-2 is the ¹³C labeled D-Arabinose (HY-N0059). D-Arabinose is is an orally active antidepressant and a growth inhibitor of C. elegans (IC₅₀ is 7.5 mM). D-Arabinose can penetrate the blood-brain barrier, selectively interfere with the metabolism of D-ribose and D-fructose, and inhibit the growth of nematodes. D-Arabinose can also inhibit the synthesis of cell biofilm and exert antibacterial activity. D-Arabinose activates the ACSS2-PPARγ/TFEB-CRTC1 axis through the lysosomal AXIN-LKB1-AMPK pathway, inducing CRTC1 transcription, exerts antidepressant-like activity. D-Arabinose is the ring-opened form of the aldopentose D-?Arabinose (HY-N7082) .

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