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Results for "

8(9)-EET

" in MedChemExpress (MCE) Product Catalog:

6

Inhibitors & Agonists

2

Natural
Products

1

Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-160431
    8(9)-EET

    		PPAR Metabolic Disease
    8(9)-EET is a major cytochrome P450 (CYP450) metabolite in the renal cortex [1][2]. It activates PPARα in HEK293 cells when used at a concentration of 1 μM but inhibits NF-κB activity induced by IL-1β in a PPARα-dependent and -independent fashion . It is also a substrate of COX-1 and COX-2, as measured by oxygen consumption and product formation assays when used at a concentration of 50 μM .
    8(9)-EET
  • HY-CE01361
    8,9-EET-CoA

    8,9-Epoxy-(5Z,11Z,14Z)-eicosatrienoyl-coenzyme A

    		 Biochemical Assay Reagents Metabolic Disease
    8,9-EET-CoA (8,9-Epoxy-(5Z,11Z,14Z)-eicosatrienoyl-coenzyme A) is a coenzyme A derivative .
    8,9-EET-CoA
  • HY-172347
    (Z)-8,9-Epoxyeicosa-14(Z)-enoic acid

    8,9-EE-14-EA

    		 Drug Derivative Others
    (Z)-8,9-Epoxyeicosa-14(Z)-enoic acid (8,9-EE-14-EA) is an analog of 8(9)-EET (HY-160431) containing one double bond. (Z)-8,9-Epoxyeicosa-14(Z)-enoic acid increases glomerular albumin permeability and has a certain antagonistic effect on the protective effect of 8(9)-EET. (Z)-8,9-Epoxyeicosa-14(Z)-enoic acid can be used in the research of glomerular dysfunction .
    (Z)-8,9-Epoxyeicosa-14(Z)-enoic acid
  • HY-150092S
    (2S,3R)-8(9)-EET-d11

    		Isotope-Labeled Compounds Drug Metabolite Others
    (2S,3R)-8(9)-EET-d11 is deuterium-labeled (2S,3R)-8(9)-EET (HY-150092) .
    (2S,3R)-8(9)-EET-d11
  • HY-N12962
    11S(12R)-EET

    		Others Others
    11S(12R)-EET is a dominant enantiomer of epoxytrienoic acid (EET) that is metabolized at a higher rate in rat organs. It shows enantiomeric-dependent reaction selectivity in hydration, especially in the case of 11,12-EET, where water addition is non-regioselective, while in 8,9-EET, water addition occurs mainly at the C9 position. In addition, 11S(12R)-EET generates diol products with specific stereochemistry through enzymatic hydration reactions, which are affected by the selective recognition of epoxidases, reaction conversion rates, and substrate binding parameters .
    11S(12R)-EET
  • HY-N12962A
    11R(12S)-EET

    		Others Others
    11R(12S)-EET is a cis-epoxytrienoic acid (EETs) derivative that is metabolized by cytoplasmic cyclooxygenases. Studies have shown that 14(R), 15(S)-, 11(S),12(R)-, and 8(S),9(R)-EETs are metabolized at significantly higher rates than their enantiomers. Enzyme-catalyzed hydration revealed that water addition was non-regioselective for the 11,12-EET enantiomers, whereas water addition occurred primarily at the C9 position for both enantiomers of 8,9-EET. These results suggest that the metabolic properties of 11R(12S)-EET and other EET enantiomers in enzyme-catalyzed processes are significantly affected by their stereostructures .
    11R(12S)-EET

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