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3 T3-L1 adipocytes

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (2) AMPK (2) Bacterial (2) c-Myc (1) Cannabinoid Receptor (1) CaSR (1) Drug Intermediate (1) Endogenous Metabolite (2) Fatty Acid Synthase (FASN) (1) Hydroxycarboxylic Acid Receptor (HCAR) (1) Lipase (1) NF-κB (2) NO Synthase (1) PPAR (9) Reactive Oxygen Species (ROS) (1) Reference Standards (3) Sirtuin (1) Stearoyl-CoA Desaturase (SCD) (1) TNF Receptor (1) Tryptophan Hydroxylase (1) Wnt (2) β-catenin (1)
By Research Areas:	Cancer (2) Infection (2) Inflammation/Immunology (4) Metabolic Disease (20)

By Targets:

Akt (2)

AMPK (2)

Bacterial (2)

c-Myc (1)

Cannabinoid Receptor (1)

CaSR (1)

Drug Intermediate (1)

Endogenous Metabolite (2)

Fatty Acid Synthase (FASN) (1)

Hydroxycarboxylic Acid Receptor (HCAR) (1)

Lipase (1)

NF-κB (2)

NO Synthase (1)

PPAR (9)

Reactive Oxygen Species (ROS) (1)

Reference Standards (3)

Sirtuin (1)

Stearoyl-CoA Desaturase (SCD) (1)

TNF Receptor (1)

Tryptophan Hydroxylase (1)

Wnt (2)

β-catenin (1)

By Research Areas:

Cancer (2)

Infection (2)

Inflammation/Immunology (4)

Metabolic Disease (20)

Inhibitors & Agonists

Peptides

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N1185

Tagitinin A	Others	Metabolic Disease
Tagitinin A is a sesquiterpene with anti-hyperglycemic activity. Tagitinin A significantly inhibits glucose uptake in differentiated 3T3-L1 adipocytes .

HY-113204

N-Oleoyl glycine 1 Publications Verification	Endogenous Metabolite Cannabinoid Receptor Akt	Metabolic Disease
N-Oleoyl glycine is a lipoamino acid, which stimulates adipogenesis associated with activation of CB1 receptor and Akt signaling pathway in 3T3-L1 adipocyte.

HY-N3027

Soyasaponin Aa	PPAR	Metabolic Disease
Soyasaponin Aa is a soyasaponin that exerts an anti-obesity effect in 3T3-L1 adipocytes through downregulation of peroxisome proliferator-activated receptor γ (PPARγ) .

HY-N4253

Kudinoside D 1 Publications Verification	Others	Metabolic Disease
Kudinoside D is a main natural component of triterpenoid saponin derived from Ilex kudingcha. Kudinoside D suppresses adipogenesis through modulation of the AMPK pathway in 3T3-L1 adipocytes .

HY-156093

TPH1-IN-1	Tryptophan Hydroxylase	Metabolic Disease
TPH1-IN-1 (compound 40) is a xanthine derivative and an inhibitor of tryptophan hydroxylase TPH1 (IC₅₀: 110.1 nM). TPH1-IN-1 has good in vitro activity and liver microsome stability, and effectively inhibits adipocyte differentiation of T3-L1 cells .

HY-133556

IQZ23	AMPK	Metabolic Disease
IQZ23 inhibits adipocyte differentiation via AMPK pathway activation. IQZ23 exerts a high efficacy in decreasing the triglyceride level (EC₅₀=0.033 μM) in 3T3-L1 adipocytes. IQZ23 could be used for the research of obesity and related metabolic disorders .

HY-N2961

Broussonin B	Others	Others
Broussonin B is a phenolic compound isolated from the stem barks of Broussonetia kanzinoki (Moraceae). Broussonin B inhibits adipocyte differentiation in 3T3-L1 cells .

HY-N7661

4β-Hydroxywithanolide E	PPAR	Metabolic Disease
4β-Hydroxywithanolide E, isolated from Physalis peruviana L., inhibits adipocyte differentiation of 3T3-L1 cells through modulation of mitotic clonal expansion. 4β-Hydroxywithanolide E is an adipogenesis inhibitor and inhibits PPARγ, C/EBPα, and the adipocyte-specific molecule aP2 mRNA expression .

HY-122959

Kihadanin B	Akt PPAR	Metabolic Disease
Kihadanin B is a citrus limonoid that can be purified from the peels of immature Citrus unshiu. Kihadanin B suppresses adipogenesis through repression of the Akt-FOXO1-PPARγ axis in 3T3-L1 adipocytes .

HY-B1419R

Salicyl alcohol (Standard) 2-Hydroxybenzyl alcohol (Standard); Saligenin (Standard)	Drug Intermediate Reference Standards	Others
Soyasaponin Aa (Standard) is the analytical standard of Soyasaponin Aa. This product is intended for research and analytical applications. Soyasaponin Aa is a soyasaponin that exerts an anti-obesity effect in 3T3-L1 adipocytes through downregulation of peroxisome proliferator-activated receptor γ (PPARγ) .

HY-N3027R

Soyasaponin Aa (Standard)	Reference Standards PPAR	Metabolic Disease
Soyasaponin Aa (Standard) is the analytical standard of Soyasaponin Aa. This product is intended for research and analytical applications. Soyasaponin Aa is a soyasaponin that exerts an anti-obesity effect in 3T3-L1 adipocytes through downregulation of peroxisome proliferator-activated receptor γ (PPARγ) .

HY-N15415

Zaluzanin C	PPAR Reactive Oxygen Species (ROS) NF-κB	Inflammation/Immunology
Zaluzanin C is a sesquiterpene lactone. Zaluzanin C has anti-inflammatory activity and can inhibit the production of mtROS, block the NF-κB signaling pathway, and reduce the production of TNF-α. In addition, Zaluzanin C can inhibit the differentiation of 3T3-L1 preadipocytes into mature adipocytes .

HY-N13160

Sanggenon F	NO Synthase	Metabolic Disease Inflammation/Immunology
Sanggenon F is a flavonoid compound derived from Morus alba var. multicaulis. It inhibits the differentiation of 3T3-L1 adipocytes and the production of nitric oxide (NO) in RAW264.7 cells induced by lipopolysaccharides (HY-D1056) and IFN-γ (IC₅₀ of 19 nM). Sanggenon F has potential application value in the fields of anti-inflammatory and metabolic diseases .

HY-12557

γ-Glutamylvaline γ-Glu-Val	CaSR Wnt TNF Receptor	Inflammation/Immunology
γ-Glutamylvaline (γ-Glu-Val) is an activator of CaSR with anti-inflammatory activity. γ-Glutamylvaline inhibits TNF-α-induced proinflammatory cytokine production and increases Wnt5a expression. γ-Glutamylvaline activates calcium-sensing receptor pathways in adipocytes of 3T3-L1 mice and prevents low-grade chronic inflammation .

HY-N7907

Myricetin-3-O-β-D-xylopyranosyl-(1→2)-β-D-glucopyranoside	Others	Metabolic Disease
Myricetin-3-O-β-D-xylopyranosyl-(1→2)-β-D-glucopyranoside is a natural product that can be obtained from sphaerophysa salsula. Myricetin-3-O-β-D-xylopyranosyl-(1→2)-β-D-glucopyranoside inhibits triglyceride (TG) accumulation in 3T3-L1 adipocytes .

HY-135982

GPR81 agonist 1 3 Publications Verification	Hydroxycarboxylic Acid Receptor (HCAR)	Metabolic Disease
GPR81 agonist 1 is a potent and highly selective GPR81 agonist, with EC₅₀s of 58 nM and 50 nM for human and mouse GPR81, respectively. GPR81 agonist 1 inhibits lipolysis in differentiated 3T3-L1 adipocytes. GPR81 agonist 1 suppresses lipolysis in mice without cutaneous flushing. GPR81 agonist 1 displays remarkable selectivity for GPR81 over GPR109a .

HY-168924

Wnt/β-catenin activator 1	Wnt β-catenin	Metabolic Disease
Wnt/β-catenin activator 1 (Compound 5m) is the orally active activator for Wnt/β-catenin signaling pathway, that arrests cell cycle at G1 phase, inhibits early proliferation of adipocytes, and inhibits adipogenesis in cell 3T3-L1 with an IC₅₀ of 330 nM. Wnt/β-catenin activator 1 exhibits anti-adipogenic and anti-dyslipidemic activities in high-fat diet fed Syrian golden hamster model .

HY-N0930B

Galegine hydrochloride	AMPK Bacterial	Infection Metabolic Disease
Galegine hydrochloride, a guanidine derivative, contributes to weight loss in mice. Guanidine hydrochloride is the compound derived from G. officinalis, which gave rise to the biguanides, metformin and phenformin. Galegine hydrochloride activates AMPK in 3T3-L1 adipocytes and L6 myotubes, as well as in the H4IIE rat hepatoma and HEK293 human kidney cell lines. Galegine hydrochloride has antibacterial activity, with minimum inhibitory concentration of 4 mg/L against Staphylococcus aureus strains .

HY-N0704

Agrimol B 1 Publications Verification	Sirtuin PPAR Fatty Acid Synthase (FASN) c-Myc Bacterial	Infection Metabolic Disease Cancer
Agrimol B, a polyphenol, is an orally active and potent SIRT1 activator. Agrimol B shows anti-adipogenic and anticancer activity. Agrimol B shows antibacterial activity against plant pathogens. Agrimol B dramatically inhibits 3T3-L1 adipocyte differentiation by reducing PPARγ, C/EBPα, FAS, UCP-1, and apoE expression. The action of Agrimol B on the cancer cells is likely derived from its effect on c-MYC, SKP2 and p27 .

HY-N11507

Tibesaikosaponin V TKV	PPAR	Metabolic Disease
Tibesaikosaponin V (TKV) is a triterpene diglycoside, which can be isolated from the methanol extract of the roots of Bupleurum chinense DC.. Tibesaikosaponin V inhibits lipid accumulation and triacylglycerol content occurred without cytotoxicity to adipocytes. Tibesaikosaponin V suppresses the mRNA expression of nuclear transcription factors, such as peroxisome proliferator-activated receptor γ (PPARγ) and CCAAT/enhancer binding protein α (C/EBPα). Tibesaikosaponin V inhibits 3T3-L1 preadipocyte differentiation. Tibesaikosaponin V can be used fro research of obesity and its associated metabolic disorders .

HY-121579

L-764406	PPAR	Others
L-764406 is a non-thiazolidinedione (TZD)-type PPARg nuclear receptor ligand with high affinity. L-764406 has significant binding ability to PPARg (IC₅₀=70 nM). L-764406 exhibited partial agonist activity and induced expression of the adipocyte-specific gene aP2 in chimeric receptors expressing the PPARg LBD and the corresponding reporter gene, as well as in 3T3-L1 cells. In contrast, L-764406 showed no activity in cells transfected with chimeric receptors containing PPARa or PPARd LBDs .

HY-N6858R

4-Hydroxyisoleucine (Standard) 4-Hydroxy-L-isoleucine (Standard)	Reference Standards Others	Metabolic Disease
4-Hydroxyisoleucine (Standard) is the analytical standard of 4-Hydroxyisoleucine. This product is intended for research and analytical applications. 4-Hydroxyisoleucine is an orally active amino acid that can be isolated from fenugreek seeds. 4-Hydroxyisoleucine displays insulinotropic and antidiabetic properties .

HY-N6858

4-Hydroxyisoleucine 4-Hydroxy-L-isoleucine	Others	Metabolic Disease
4-Hydroxyisoleucine is an orally active amino acid that can be isolated from fenugreek seeds. 4-Hydroxyisoleucine displays insulinotropic and antidiabetic properties .

HY-116538

(10E,12Z)-Octadeca-10,12-dienoic acid trans-10,cis-12 CLA2	Endogenous Metabolite PPAR NF-κB Stearoyl-CoA Desaturase (SCD) Lipase	Metabolic Disease Inflammation/Immunology Cancer
(10E,12Z)-Octadeca-10,12-dienoic acid (trans-10,cis-12 CLA2) is an orally active PPARα activator and inhibits *adipocyte* differentiation. (10E,12Z)-Octadeca-10,12-dienoic acid and its downstream metabolites have various antioxidant and antitumor activities. (10E,12Z)-Octadeca-10,12-dienoic acid can induce proinflammatory cytokines and chemokines, which would lead to decreased adipogenesis and insulin resistance in adipose tissue. (10E,12Z)-Octadeca-10,12-dienoic acid can affect many aspects of milk fat synthesis. (10E,12Z)-Octadeca-10,12-dienoic acid reduces expression of lipogenic enzymes and inhibits the desaturation of fatty acids. (10E,12Z)-Octadeca-10,12-dienoic acid can reduce lipoprotein lipase (LPL) activity in cultured 3T3-L1 adipocytes and enhance triacylglycerol release from these cells. (10E,12Z)-Octadeca-10,12-dienoic acid decreases the expression of hepatic stearoyl-CoA desatyrase mRNA in mice. (10E,12Z)-Octadeca-10,12-dienoic acid is associated with changes in mucosal NF-κB and Cyclin D1 protein levels in mice .

Cat. No.	Product Name	Target	Research Area

HY-12557

γ-Glutamylvaline γ-Glu-Val	CaSR Wnt TNF Receptor	Inflammation/Immunology
γ-Glutamylvaline (γ-Glu-Val) is an activator of CaSR with anti-inflammatory activity. γ-Glutamylvaline inhibits TNF-α-induced proinflammatory cytokine production and increases Wnt5a expression. γ-Glutamylvaline activates calcium-sensing receptor pathways in adipocytes of 3T3-L1 mice and prevents low-grade chronic inflammation .

HY-125357

Ternatin	Peptides	Metabolic Disease
Ternatin (compound 2) is a cyclic heptapeptides that can be isolated from mushroom Coliorus versicolor. Ternatin inhibits fat-accumulation with an IC₅₀ of 0.027 μM in *3T3-L1* adipocytes .

Tagitinin A	Structural Classification Terpenoids Sesquiterpenes Source classification Plants Tithonia diversifolia A. Gray. Compositae	Others
Tagitinin A is a sesquiterpene with anti-hyperglycemic activity. Tagitinin A significantly inhibits glucose uptake in differentiated 3T3-L1 adipocytes .

N-Oleoyl glycine 1 Publications Verification	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite Cannabinoid Receptor Akt
N-Oleoyl glycine is a lipoamino acid, which stimulates adipogenesis associated with activation of CB1 receptor and Akt signaling pathway in 3T3-L1 adipocyte.

Soyasaponin Aa	Triterpenes Structural Classification Classification of Application Fields Leguminosae Glycine max (L.) merr Terpenoids Source classification Metabolic Disease Plants Disease Research Fields	PPAR
Soyasaponin Aa is a soyasaponin that exerts an anti-obesity effect in 3T3-L1 adipocytes through downregulation of peroxisome proliferator-activated receptor γ (PPARγ) .

Kudinoside D 1 Publications Verification	Natural Products other families Classification of Application Fields Source classification Metabolic Disease Plants Disease Research Fields	Others
Kudinoside D is a main natural component of triterpenoid saponin derived from Ilex kudingcha. Kudinoside D suppresses adipogenesis through modulation of the AMPK pathway in 3T3-L1 adipocytes .

Broussonin B	Structural Classification Source classification Phenols Polyphenols Broussonetia × kazinoki Siebold Plants Moraceae	Others
Broussonin B is a phenolic compound isolated from the stem barks of Broussonetia kanzinoki (Moraceae). Broussonin B inhibits adipocyte differentiation in 3T3-L1 cells .

4β-Hydroxywithanolide E	Source classification Plants Solanaceae Steroids	PPAR
4β-Hydroxywithanolide E, isolated from Physalis peruviana L., inhibits adipocyte differentiation of 3T3-L1 cells through modulation of mitotic clonal expansion. 4β-Hydroxywithanolide E is an adipogenesis inhibitor and inhibits PPARγ, C/EBPα, and the adipocyte-specific molecule aP2 mRNA expression .

Kihadanin B	Other Terpenoids Structural Classification Terpenoids Dictamnus dasycarpus Turcz. Source classification Rutaceae Plants	Akt PPAR
Kihadanin B is a citrus limonoid that can be purified from the peels of immature Citrus unshiu. Kihadanin B suppresses adipogenesis through repression of the Akt-FOXO1-PPARγ axis in 3T3-L1 adipocytes .

Salicyl alcohol (Standard) 2-Hydroxybenzyl alcohol (Standard); Saligenin (Standard)	Structural Classification Monophenols Microorganisms Source classification Phenols	Drug Intermediate Reference Standards
Soyasaponin Aa (Standard) is the analytical standard of Soyasaponin Aa. This product is intended for research and analytical applications. Soyasaponin Aa is a soyasaponin that exerts an anti-obesity effect in 3T3-L1 adipocytes through downregulation of peroxisome proliferator-activated receptor γ (PPARγ) .

Soyasaponin Aa (Standard)	Triterpenes Structural Classification Leguminosae Glycine max (L.) merr Terpenoids Source classification Plants	Reference Standards PPAR
Soyasaponin Aa (Standard) is the analytical standard of Soyasaponin Aa. This product is intended for research and analytical applications. Soyasaponin Aa is a soyasaponin that exerts an anti-obesity effect in 3T3-L1 adipocytes through downregulation of peroxisome proliferator-activated receptor γ (PPARγ) .

Zaluzanin C	Structural Classification Strobocalyx arborea (Buch.-Ham.) Sch. Bip. Terpenoids Sesquiterpenes Source classification Plants Compositae	PPAR Reactive Oxygen Species (ROS) NF-κB
Zaluzanin C is a sesquiterpene lactone. Zaluzanin C has anti-inflammatory activity and can inhibit the production of mtROS, block the NF-κB signaling pathway, and reduce the production of TNF-α. In addition, Zaluzanin C can inhibit the differentiation of 3T3-L1 preadipocytes into mature adipocytes .

Sanggenon F	Structural Classification Flavonoids Flavonones Source classification Plants Moraceae Morus alba Linn.	NO Synthase
Sanggenon F is a flavonoid compound derived from Morus alba var. multicaulis. It inhibits the differentiation of 3T3-L1 adipocytes and the production of nitric oxide (NO) in RAW264.7 cells induced by lipopolysaccharides (HY-D1056) and IFN-γ (IC₅₀ of 19 nM). Sanggenon F has potential application value in the fields of anti-inflammatory and metabolic diseases .

Myricetin-3-O-β-D-xylopyranosyl-(1→2)-β-D-glucopyranoside	Structural Classification Leguminosae Phenols Polyphenols Plants Sphaerophysa salsula	Others
Myricetin-3-O-β-D-xylopyranosyl-(1→2)-β-D-glucopyranoside is a natural product that can be obtained from sphaerophysa salsula. Myricetin-3-O-β-D-xylopyranosyl-(1→2)-β-D-glucopyranoside inhibits triglyceride (TG) accumulation in 3T3-L1 adipocytes .

Galegine hydrochloride	Alkaloids Structural Classification Classification of Application Fields Leguminosae Other Alkaloids Source classification Metabolic Disease Plants Galega officinalis Linn. Disease Research Fields	AMPK Bacterial
Galegine hydrochloride, a guanidine derivative, contributes to weight loss in mice. Guanidine hydrochloride is the compound derived from G. officinalis, which gave rise to the biguanides, metformin and phenformin. Galegine hydrochloride activates AMPK in 3T3-L1 adipocytes and L6 myotubes, as well as in the H4IIE rat hepatoma and HEK293 human kidney cell lines. Galegine hydrochloride has antibacterial activity, with minimum inhibitory concentration of 4 mg/L against Staphylococcus aureus strains .

Agrimol B 1 Publications Verification	Agrimonia pilosa Ledeb. Structural Classification Classification of Application Fields Rosaceae Phenols Polyphenols Metabolic Disease Plants Disease Research Fields	Sirtuin PPAR Fatty Acid Synthase (FASN) c-Myc Bacterial
Agrimol B, a polyphenol, is an orally active and potent SIRT1 activator. Agrimol B shows anti-adipogenic and anticancer activity. Agrimol B shows antibacterial activity against plant pathogens. Agrimol B dramatically inhibits 3T3-L1 adipocyte differentiation by reducing PPARγ, C/EBPα, FAS, UCP-1, and apoE expression. The action of Agrimol B on the cancer cells is likely derived from its effect on c-MYC, SKP2 and p27 .

Tibesaikosaponin V TKV	Triterpenes Structural Classification Sonchus asper (L.) Hill Terpenoids Source classification Plants Umbelliferae	PPAR
Tibesaikosaponin V (TKV) is a triterpene diglycoside, which can be isolated from the methanol extract of the roots of Bupleurum chinense DC.. Tibesaikosaponin V inhibits lipid accumulation and triacylglycerol content occurred without cytotoxicity to adipocytes. Tibesaikosaponin V suppresses the mRNA expression of nuclear transcription factors, such as peroxisome proliferator-activated receptor γ (PPARγ) and CCAAT/enhancer binding protein α (C/EBPα). Tibesaikosaponin V inhibits 3T3-L1 preadipocyte differentiation. Tibesaikosaponin V can be used fro research of obesity and its associated metabolic disorders .

4-Hydroxyisoleucine (Standard) 4-Hydroxy-L-isoleucine (Standard)	Structural Classification other families Leguminosae Ketones, Aldehydes, Acids Source classification Plants Trigonella foenum-graecum Linn.	Reference Standards Others
4-Hydroxyisoleucine (Standard) is the analytical standard of 4-Hydroxyisoleucine. This product is intended for research and analytical applications. 4-Hydroxyisoleucine is an orally active amino acid that can be isolated from fenugreek seeds. 4-Hydroxyisoleucine displays insulinotropic and antidiabetic properties .

4-Hydroxyisoleucine 4-Hydroxy-L-isoleucine	Structural Classification other families Classification of Application Fields Leguminosae Ketones, Aldehydes, Acids Source classification Metabolic Disease Plants Trigonella foenum-graecum Linn. Disease Research Fields	Others
4-Hydroxyisoleucine is an orally active amino acid that can be isolated from fenugreek seeds. 4-Hydroxyisoleucine displays insulinotropic and antidiabetic properties .

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