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2-Hydroxyglutarate disodium (Standard)

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-113038AR
    α-Hydroxyglutaric acid disodium (Standard)

    2-Hydroxyglutarate disodium (Standard); 2-Hydroxyglutaric acid disodium (Standard); 2-Hydroxypentanedioic acid disodium (Standard)

    		 Reference Standards Histone Demethylase Endogenous Metabolite Cancer
    Ophiopogonin D (Standard) is the analytical standard of Ophiopogonin D. This product is intended for research and analytical applications. Ophiopogonin D, isolated from the tubers of Ophiopogon japonicus, is a rare naturally occurring C29 steroidal glycoside . Ophiopogonin D is a CYP2J3 inducer that significantly inhibits Ang II induced NF-κB nuclear translocation, IκBα down-regulation, intracellular Ca2+ overload and activation of pro-inflammatory cytokines by increasing the expression of CYP2J2/EETs and PPARα in human umbilical vein endothelial cells (HUVECs). Ophiopogonin D has been used to treat inflammatory and cardiovascular diseases for thousands of years .
    α-Hydroxyglutaric acid disodium (Standard)
  • HY-100542R
    D-α-Hydroxyglutaric acid disodium (Standard)

    disodium (R)-2-Hydroxyglutarate (Standard)

    		 Reference Standards Reactive Oxygen Species (ROS) ATP Synthase mTOR Endogenous Metabolite Neurological Disease Inflammation/Immunology Cancer
    D-α-Hydroxyglutaric acid (disodium) (Standard) is the analytical standard of D-α-Hydroxyglutaric acid (disodium). This product is intended for research and analytical applications. D-α-Hydroxyglutaric acid disodium (Disodium (R)-2-hydroxyglutarate) is the principal metabolite accumulating in neurometabolic disease D-2-hydroxyglutaric aciduria. D-α-Hydroxyglutaric acid disodium is a weak competitive antagonist of α-ketoglutarate (α-KG) and inhibits multiple α-KG-dependent dioxygenases with a Ki of 10.87 mM. D-α-Hydroxyglutaric acid disodium increases reactive oxygen species (ROS) production. D-α-Hydroxyglutaric acid disodium binds and inhibits ATP synthase and inhibits mTOR signaling .
    D-α-Hydroxyglutaric acid disodium (Standard)

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