1. Search Result
Search Result
Results for "


" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-P99965

    SKY59; RO7112689

    Complement System Cardiovascular Disease Metabolic Disease
    Crovalimab (SKY59; RO7112689) is a novel humanized antibody against C5 in a pH-dependent manner with KDs of 15.2 nM and 16.8 μM at pH 7.4 and 5.8, respectively. Crovalimab binds human FcRn with great affinity (KD: 17 μM at pH 6.0). Crovalimab can block cleavage of C5 by the C5 convertase and inhibite the activity of a C5 variant (p.Arg885His). Crovalimab inhibits C5b-9 formation significantly in all three complement pathways, the classical pathway (CP), lectin pathway (LP), and alternative pathway (AP). Crovalimab has the potential for paroxysmal nocturnal hemoglobinuria (PNH) and complement-mediated diseases research .

Inquiry Online

Your information is safe with us. * Required Fields.



Country or Region *

Applicant Name *


Organization Name *

Department *


Email Address *


Product Name *

Cat. No.


Requested quantity *

Phone Number *



Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
MCE Japan Authorized Agent: