SREBP2

By Targets:	Apoptosis (3) Autophagy (3) Bacterial (1) Endogenous Metabolite (2) ERK (3) Estrogen Receptor/ERR (1) Fatty Acid Synthase (FASN) (2) Liposome (1) PCSK9 (2) Reference Standards (1) Small Interfering RNA (siRNA) (3)
By Research Areas:	Cancer (6) Cardiovascular Disease (2) Metabolic Disease (2) Neurological Disease (3)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Emulsifiers (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W510159

5-O-Methylembelin	PCSK9	Cardiovascular Disease
5-O-Methylembelin is a natural isocoumarin that inhibits PCSK9, inducible degrader of the low-density lipoprotein receptor (IDLR), and sterol regulatory element binding protein 2 (SREBP2) mRNA expression .

HY-14452

Fatostatin 30+ Cited Publications 125B11	Fatty Acid Synthase (FASN)	Cancer
Fatostatin (125B11), a specific inhibitor of SREBP activation, impairs the activation of SREBP-1 and SREBP-2. Fatostatin binds to SCAP (SREBP cleavage-activating protein), and inhibits the ER-Golgi translocation of SREBPs. Fatostatin decreases the transcription of lipogenic genes in cells. Fatostatin possesses antitumor properties, and lowers hyperglycemia in ob/ob mice ^[2].

HY-14452A

Fatostatin hydrobromide 30+ Cited Publications 125B11 hydrobromide	Fatty Acid Synthase (FASN)	Cancer
Fatostatin hydrobromide (125B11 hydrobromide), a specific inhibitor of SREBP activation, impairs the activation of SREBP-1 and SREBP-2. Fatostatin hydrobromide binds to SCAP (SREBP cleavage-activating protein), and inhibits the ER-Golgi translocation of SREBPs. Fatostatin hydrobromide decreases the transcription of lipogenic genes in cells. Fatostatin hydrobromide possesses antitumor properties, and lowers hyperglycemia in ob/ob mice ^[2].

HY-111355B

Cholesteryl sulfate sodium	Endogenous Metabolite	Metabolic Disease
Cholesteryl sulfate sodium is an orally available, *NPC2*-targeted cholesterol biosynthesis agonist. Cholesteryl sulfate sodium activates SREBP2 by competitively binding to NPC2, promoting cholesterol synthesis (EC₅₀=50 μM). Cholesteryl sulfate sodium enhances the self-assembly ability of Mitoxantrone hydrochloride (HY-13502A), while repairing the intestinal mucosal barrier and inhibiting inflammation by regulating serine protease activity and PKCη signaling pathway. Cholesteryl sulfate sodium is a component of the platelet cell membrane and supports platelet adhesion. Cholesteryl sulfate sodium also regulates the activity of selective protein kinase C isoforms and modulates the specificity of PI3K, playing a role in keratinocyte differentiation ^[2] .

HY-N0322

Cholesterol Maximum Cited Publications 41 Publications Verification	Liposome Estrogen Receptor/ERR Endogenous Metabolite Bacterial	Metabolic Disease Cancer
Cholesterol is the major sterol in mammals. It is making up 20-25% of structural component of the plasma membrane. Plasma membranes are highly permeable to water but relatively impermeable to ions and protons. Cholesterol plays an important role in determining the fluidity and permeability characteristics of the membrane as well as the function of both the transporters and signaling proteins ^[2]. Cholesterol is also an endogenous estrogen-related receptor α (ERRα) agonist .

HY-B0444R

Maprotiline hydrochloride (Standard) 4 Publications Verification	Reference Standards Autophagy Apoptosis ERK	Neurological Disease Cancer
Maprotiline (hydrochloride) (Standard) is the analytical standard of Maprotiline (hydrochloride). Maprotiline (hydrochloride) (Standard) is a highly selective noradrenergic reuptake inhibitor that has strong antidepressant, antitumor and neuropathic pain-relieving effects. Maprotiline (hydrochloride) (Standard) induces cancer cell apoptosis by targeting the ERK signaling pathway and CRABP1 ^[2].

HY-RS13758

SREBF2 Human Pre-designed siRNA Set A SREBP2; bHLHd2; SREBP-2	Small Interfering RNA (siRNA)	Others
SREBF2 Human Pre-designed siRNA Set A contains three designed siRNAs for SREBF2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SREBF2 Human Pre-designed siRNA Set A SREBF2 Human Pre-designed siRNA Set A

HY-RS28463

Srebf2 Rat Pre-designed siRNA Set A SREBP-2; SREBP2; Srebf2_retired	Small Interfering RNA (siRNA)	Others
Srebf2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Srebf2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Srebf2 Rat Pre-designed siRNA Set A Srebf2 Rat Pre-designed siRNA Set A

HY-RS21946

Srebf2 Mouse Pre-designed siRNA Set A nuc; lop13; SREBP2; bHLHd2; SREBP-2; SREBP2gc	Small Interfering RNA (siRNA)	Others
Srebf2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Srebf2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Srebf2 Mouse Pre-designed siRNA Set A Srebf2 Mouse Pre-designed siRNA Set A

HY-N10702

PCSK9-IN-9	PCSK9	Cardiovascular Disease
PCSK9-IN-9 is an isocoumarins of natural origin. PCSK9-IN-9 can inhibit proprotein convertase subtilisin-kexin type 9 (PCSK9), IDOL, and *SREBP2* mRNA expression. PCSK9-IN-9 inhibits PCSK9 with an IC₅₀ value of 11.9 μM .

HY-B0444A

Maprotiline	Autophagy Apoptosis ERK	Neurological Disease Cancer
Maprotiline is a highly selective noradrenergic reuptake inhibitor that has strong antidepressant, antitumor and neuropathic pain-relieving effects. Maprotiline induces cancer cell apoptosis by targeting the ERK signaling pathway and CRABP1 ^[2].

HY-B0444

Maprotiline hydrochloride 4 Publications Verification	Autophagy Apoptosis ERK	Neurological Disease Cancer
Maprotiline hydrochloride is a highly selective noradrenergic reuptake inhibitor that has strong antidepressant, antitumor and neuropathic pain-relieving effects with oral activity. Maprotiline hydrochloride induces cancer cell apoptosis by targeting the ERK signaling pathway and CRABP1 ^[2].

Cat. No.	Product Name	Type

HY-N0322

Cholesterol 40+ Cited Publications	Drug Delivery
Cholesterol is the major sterol in mammals. It is making up 20-25% of structural component of the plasma membrane. Plasma membranes are highly permeable to water but relatively impermeable to ions and protons. Cholesterol plays an important role in determining the fluidity and permeability characteristics of the membrane as well as the function of both the transporters and signaling proteins ^[2]. Cholesterol is also an endogenous estrogen-related receptor α (ERRα) agonist .

Cholesterol

40+ Cited Publications

Drug Delivery

Cholesterol is the major sterol in mammals. It is making up 20-25% of structural component of the plasma membrane. Plasma membranes are highly permeable to water but relatively impermeable to ions and protons. Cholesterol plays an important role in determining the fluidity and permeability characteristics of the membrane as well as the function of both the transporters and signaling proteins ^[2]. Cholesterol is also an endogenous estrogen-related receptor α (ERRα) agonist .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W510159

5-O-Methylembelin	Structural Classification Lysimachia vulgarisL. Source classification Coumarins Phenylpropanoids Plants Primulaceae	PCSK9
5-O-Methylembelin is a natural isocoumarin that inhibits PCSK9, inducible degrader of the low-density lipoprotein receptor (IDLR), and sterol regulatory element binding protein 2 (SREBP2) mRNA expression .

HY-111355B

Cholesteryl sulfate sodium	Structural Classification Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Steroids	Endogenous Metabolite
Cholesteryl sulfate sodium is an orally available, *NPC2*-targeted cholesterol biosynthesis agonist. Cholesteryl sulfate sodium activates SREBP2 by competitively binding to NPC2, promoting cholesterol synthesis (EC₅₀=50 μM). Cholesteryl sulfate sodium enhances the self-assembly ability of Mitoxantrone hydrochloride (HY-13502A), while repairing the intestinal mucosal barrier and inhibiting inflammation by regulating serine protease activity and PKCη signaling pathway. Cholesteryl sulfate sodium is a component of the platelet cell membrane and supports platelet adhesion. Cholesteryl sulfate sodium also regulates the activity of selective protein kinase C isoforms and modulates the specificity of PI3K, playing a role in keratinocyte differentiation ^[2] .

HY-N0322

Cholesterol 40+ Cited Publications	Structural Classification Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Steroids Cancer	Liposome Estrogen Receptor/ERR Endogenous Metabolite Bacterial
Cholesterol is the major sterol in mammals. It is making up 20-25% of structural component of the plasma membrane. Plasma membranes are highly permeable to water but relatively impermeable to ions and protons. Cholesterol plays an important role in determining the fluidity and permeability characteristics of the membrane as well as the function of both the transporters and signaling proteins ^[2]. Cholesterol is also an endogenous estrogen-related receptor α (ERRα) agonist .

HY-N10702

PCSK9-IN-9	Structural Classification Lysimachia vulgarisL. Source classification Coumarins Phenylpropanoids Plants Primulaceae	PCSK9
PCSK9-IN-9 is an isocoumarins of natural origin. PCSK9-IN-9 can inhibit proprotein convertase subtilisin-kexin type 9 (PCSK9), IDOL, and *SREBP2* mRNA expression. PCSK9-IN-9 inhibits PCSK9 with an IC₅₀ value of 11.9 μM .

Cat. No.	Product Name		Classification

HY-N0322

Cholesterol 40+ Cited Publications		Emulsifiers
Cholesterol is the major sterol in mammals. It is making up 20-25% of structural component of the plasma membrane. Plasma membranes are highly permeable to water but relatively impermeable to ions and protons. Cholesterol plays an important role in determining the fluidity and permeability characteristics of the membrane as well as the function of both the transporters and signaling proteins ^[2]. Cholesterol is also an endogenous estrogen-related receptor α (ERRα) agonist .

HY-RS13758

SREBF2 Human Pre-designed siRNA Set A SREBP2; bHLHd2; SREBP-2		siRNAs Human Pre-designed siRNA Sets
SREBF2 Human Pre-designed siRNA Set A contains three designed siRNAs for SREBF2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS28463

Srebf2 Rat Pre-designed siRNA Set A SREBP-2; SREBP2; Srebf2_retired		siRNAs Rat Pre-designed siRNA Sets
Srebf2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Srebf2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS21946

Srebf2 Mouse Pre-designed siRNA Set A nuc; lop13; SREBP2; bHLHd2; SREBP-2; SREBP2gc		siRNAs Mouse Pre-designed siRNA Sets
Srebf2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Srebf2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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SREBP2

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