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SP-A

" in MedChemExpress (MCE) Product Catalog:

By Targets:	11β-HSD (1) ADC Cytotoxin (3) Akt (1) Antibiotic (4) Apoptosis (3) Bacterial (4) CETP (2) COX (1) Drug Isomer (1) Endogenous Metabolite (1) Fungal (1) HIF/HIF Prolyl-Hydroxylase (2) Histone Methyltransferase (2) Huntingtin (1) Influenza Virus (1) Insulin Receptor (3) Interleukin Related (1) Isotope-Labeled Compounds (1) Lipocalin Family (1) METTL3 (1) Microtubule/Tubulin (5) NF-κB (1) p38 MAPK (1) RANKL/RANK (1) Reference Standards (1) RSV (1) Ser/Thr Protease (1) SGK (1) Small Interfering RNA (siRNA) (7)
By Research Areas:	Cancer (15) Cardiovascular Disease (3) Infection (7) Inflammation/Immunology (5) Metabolic Disease (5) Neurological Disease (1)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (2) Human Pre-designed siRNA Sets (4) Antisense Oligonucleotides (1) siRNAs (7)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-NP006

Protein A SPA	Endogenous Metabolite	Inflammation/Immunology
Protein A (SPA) is an immunoglobulin (Ig) binding protein that exists on the surface of bacteria and can be freely secreted into the extracellular environment. Protein A blocks opsonization and phagocytosis and induces B-cell death in vitro by binding to the Fc region of antibodies and the Fab region of B-cell receptors. Protein A has the ability to inhibit opsonization and phagocytosis in vitro .

HY-124830

SPA70	Others	Cancer
SPA70 is a potent and selective antagonist of human pregnane X receptor (hPXR), with an IC₅₀ of 540 nM (K_i=390 nM). SPA70 can enhance the chemosensitivity of cancer cells .

HY-RS12780

SFTPA1 Human Pre-designed siRNA Set A SPA; ILD1; PSAP; PSPA; SP-A; SPA1; PSP-A; SFTP1; SP-A1; COLEC4; SFTPA1B; SP-A1 beta; SP-A1 delta; SP-A1 gamma; SP-A1 epsilon	Small Interfering RNA (siRNA)	Others
SFTPA1 Human Pre-designed siRNA Set A contains three designed siRNAs for SFTPA1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SFTPA1 Human Pre-designed siRNA Set A SFTPA1 Human Pre-designed siRNA Set A

HY-RS12781

SFTPA2 Human Pre-designed siRNA Set A ILD2; PSAP; PSPA; SP-A; SPA2; PSP-A; SFTP1; SP-2A; SPAII; COLEC5; SFTPA2B	Small Interfering RNA (siRNA)	Others
SFTPA2 Human Pre-designed siRNA Set A contains three designed siRNAs for SFTPA2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SFTPA2 Human Pre-designed siRNA Set A SFTPA2 Human Pre-designed siRNA Set A

HY-RS22187

Glrb Mouse Pre-designed siRNA Set A SPa; Glyrb; SPastic	Small Interfering RNA (siRNA)	Others
Glrb Mouse Pre-designed siRNA Set A contains three designed siRNAs for Glrb gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Glrb Mouse Pre-designed siRNA Set A Glrb Mouse Pre-designed siRNA Set A

HY-169703

SPA0355	RANKL/RANK p38 MAPK Akt NF-κB	Inflammation/Immunology
SPA0355 is a thiourea derivative that has antioxidant and anti-inflammatory properties. SPA0355 inhibits the RANKL (receptor activator of nuclear factor κB ligand) induced osteoclast formation in primary bone marrow-derived macrophages. SPA0355 also suppresses the activation of the MAPKs, Akt, and NF-κB pathways. Additionally, SPA0355 promotes osteoblast differentiation, increases alkaline phosphatase activity, and enhances mineral nodule formation. SPA0355 can protect ovariectomized mice from bone loss by stimulating osteoblast differentiation and inhibiting osteoclast resorption, making it useful for studying postmenopausal osteoporosis .

HY-109125A

Amcipatricin L-aspartate SPA-S-753; SPA-S-752 L-aSPartate	Antibiotic Fungal	Infection
Amcipatricin diaspartate (SPA-S-753) is a semi-synthetic polyene antibiotic, with potent broad-spectrum antifungal activity .

HY-P10354

SPA4	Interleukin Related	Inflammation/Immunology
SPA4 is a TLR4-interacting peptide. SPA4 inhibits the LPS-induced TNF-α cytokine response without effect the cell viability or size .

HY-164923

SPA107 Hemiasterlin methyl ester	Microtubule/Tubulin	Cancer
SPA107 (Hemiasterlin methyl ester) is a Hemiasterlin (HY-117371) analog. SPA107 inhibits the polymerization of tubulin, exhibits antimitotic activity (IC₅₀ of 0.5 nM) and cytotoxicity in p53 mutated MCF-7 cell with IC₅₀ of 0.5 nM .

HY-RS21050

Spa17 Mouse Pre-designed siRNA Set A SP17	Small Interfering RNA (siRNA)	Others
Spa17 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Spa17 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Spa17 Mouse Pre-designed siRNA Set A Spa17 Mouse Pre-designed siRNA Set A

HY-RS27568

Spa17 Rat Pre-designed siRNA Set A SP17	Small Interfering RNA (siRNA)	Others
Spa17 Rat Pre-designed siRNA Set A contains three designed siRNAs for Spa17 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Spa17 Rat Pre-designed siRNA Set A Spa17 Rat Pre-designed siRNA Set A

HY-RS13613

SPA17 Human Pre-designed siRNA Set A CT22; SP17; SP17-1	Small Interfering RNA (siRNA)	Others
SPA17 Human Pre-designed siRNA Set A contains three designed siRNAs for SPA17 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SPA17 Human Pre-designed siRNA Set A SPA17 Human Pre-designed siRNA Set A

HY-15584A

Taltobulin trifluoroacetate 3 Publications Verification HTI-286 trifluoroacetate; SPA-110 trifluoroacetate	Microtubule/Tubulin ADC Cytotoxin Apoptosis	Cancer
Taltobulin trifluoroacetate (HTI-286 trifluoroacetate), a synthetic analogue of the tripeptide hemiasterlin, is a potent antimicrotubule agent that circumvents P-glycoprotein-mediated resistance in vitro and in vivo. Taltobulin trifluoroacetate inhibits the polymerization of purified tubulin, disrupts microtubule organization in cells, and induces mitotic arrest, as well as apoptosis .

HY-15584B

Taltobulin hydrochloride 3 Publications Verification HTI-286 hydrochloride; SPA-110 hydrochloride	Microtubule/Tubulin ADC Cytotoxin Apoptosis	Cancer
Taltobulin hydrochloride (HTI-286 hydrochloride), a synthetic analogue of the tripeptide hemiasterlin, is a potent antimicrotubule agent that circumvents P-glycoprotein-mediated resistance in vitro and in vivo. Taltobulin hydrochloride inhibits the polymerization of purified tubulin, disrupts microtubule organization in cells, and induces mitotic arrest, as well as apoptosis .

HY-15584

Taltobulin 3 Publications Verification HTI-286; SPA-110	Microtubule/Tubulin ADC Cytotoxin Apoptosis	Cancer
Taltobulin (HTI-286), a synthetic analogue of the tripeptide hemiasterlin, is a potent antimicrotubule agent that circumvents P-glycoprotein-mediated resistance in vitro and in vivo. Taltobulin inhibits the polymerization of purified tubulin, disrupts microtubule organization in cells, and induces mitotic arrest, as well as apoptosis .

HY-106583

Piroxicam cinnamate Cinnoxicam; SPA-S-510; Sinartol	COX	Inflammation/Immunology
Piroxicam cinnamate (Cinnoxicam) is a cyclooxygenase (COX) inhibitor, with anti-inflammatory activity. Piroxicam cinnamate is stable under gastric conditions, can be used for inflammatory-degenerative osteoarticular diseases, rheumatic disorders, and varicocele (VC) associated oligoasthenospermia research .

HY-10844

Pretomanid 5+ Cited Publications PA-824; (S)-PA 824	Bacterial Antibiotic	Infection Cancer
Pretomanid (PA-824) is an antibiotic used for the research of multi-drug-resistant tuberculosis affecting the lungs. Pretomanid exhibits a sub-micromolar MIC against M. tuberculosis (MTB). The MIC values of PA-824 against a panel of MTB pan-sensitive and Rifampin mono-resistant clinical isolates range from 0.015 to 0.25 μg/mL.

HY-RS12928

SIPA1 Human Pre-designed siRNA Set A SPA1	Small Interfering RNA (siRNA)	Others
SIPA1 Human Pre-designed siRNA Set A contains three designed siRNAs for SIPA1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SIPA1 Human Pre-designed siRNA Set A SIPA1 Human Pre-designed siRNA Set A

HY-10844R

Pretomanid (Standard) PA-824 (Standard); (S)-PA 824 (Standard)	Reference Standards Bacterial Antibiotic	Infection Cancer
Pretomanid (Standard) is the analytical standard of Pretomanid. This product is intended for research and analytical applications. Pretomanid (PA-824) is an antibiotic used for the research of multi-drug-resistant tuberculosis affecting the lungs. Pretomanid exhibits a sub-micromolar MIC against M. tuberculosis (MTB). The MIC values of PA-824 against a panel of MTB pan-sensitive and Rifampin mono-resistant clinical isolates range from 0.015 to 0.25 μg/mL.

HY-10844S1

Pretomanid-d5 PA-824-d₅; (S)-PA 824-d₅	Antibiotic Bacterial Isotope-Labeled Compounds	Infection Cancer
Pretomanid-d₅ is deuterated labeled Pretomanid (HY-10844). Pretomanid (PA-824) is an antibiotic used for the research of multi-drug-resistant tuberculosis affecting the lungs. Pretomanid exhibits a sub-micromolar MIC against M. tuberculosis (MTB). The MIC values of PA-824 against a panel of MTB pan-sensitive and Rifampin mono-resistant clinical isolates range from 0.015 to 0.25 μg/mL.

HY-P99770

Omodenbamab 514-G3	Bacterial	Infection
Omodenbamab is an anti-SpA (Staphylococcal protein A) human monoclonal antibody with a K_D value of 0.0467 nM. Omodenbamab circumvents a key S. aureus evasion mechanism by targeting the cell wall moiety Protein A (SpA). Omodenbamab can be used in research of S. aureus bloodstream infection .

HY-132579

Tominersen RG6042; IONIS-HTTRx	Huntingtin	Neurological Disease
Tominersen (RG6042) is a second-generation 2′-O-(2-methoxyethyl) antisense oligonucleotide that targets huntingtin protein (HTT) mRNA and potently suppresses HTT production. Tominersen improves survival and reduces brain atrophy in mice. Tominersen can be used for the research of Huntington’s disease (HD) .

HY-15192

GSK 650394 Maximum Cited Publications 17 Publications Verification	SGK Influenza Virus	Infection Cancer
GSK 650394 is a novel SGK inhibitor with IC₅₀ of 62 nM and 103 nM for SGK1 and SGK2 in the SPA assay respectively. GSK 650394 also inhibits influenza virus replication.

HY-15584C

(R)-Taltobulin (R)-HTI-286; (R)-SPA-110	Microtubule/Tubulin Drug Isomer	Others
(R)-Taltobulin ((R)-HTI-286) can be used as a reference substance .

HY-135127

Dot1L-IN-4 1 Publications Verification	Histone Methyltransferase	Cancer
Dot1L-IN-4 is a potent disruptor of telomeric silencing 1-like protein (DOT1L) inhibitor with an IC_{50 SPA DOT1L} of 0.11 nM .

HY-135129

Dot1L-IN-6	Histone Methyltransferase	Cancer
Dot1L-IN-6 is a potent disruptor of telomeric silencing 1-like protein (DOT1L) inhibitor with an IC_{50 SPA DOT1L} of 0.19 nM .

HY-19614

BMS-795311	CETP	Cardiovascular Disease
BMS-795311 is a potent and orally bioavailable inhibitor of cholesteryl ester transfer protein (CETP), with IC₅₀s of 4 nM in an enzyme-based scintillation proximity assay (SPA) and 0.22 μM in a human whole plasma assay (hWPA), respectively .

HY-172452

RSV L-protein-6	RSV	Infection
RSV L-protein-6 (Compound 19a) is a respiratory syncytial virus polymerase inhibitor, with an IC₅₀ of 13 nM in SPA primer extensions enzymatic assay. RSV L-protein-6 can inhibit RSV replication in Hela cells .

HY-130264

HIF-2α-IN-2	HIF/HIF Prolyl-Hydroxylase	Cancer
HIF-2α-IN-2 is a hypoxia-inducible factors (HIF-2α) inhibitor extracted from patent WO2015035223A1, Compound 232, has an IC₅₀ of 16 nM in scintillation proximity assay (SPA) .

HY-168878

EP652	METTL3	Cancer
EP652 (compound 56) potently inhibits the enzymatic activity of METTL3, with the IC₅₀s of 2 nM, ＜ 10 nM anf 37 nM in SPA, intracellular and ATPlite assay, respectively. EP652 plays an important role in liquid and solid tumors research .

HY-P2093

S961 5 Publications Verification	Insulin Receptor	Metabolic Disease
S961 is an high-affinity and selective insulin receptor (IR) antagonist with IC₅₀s of 0.048, 0.027, and 630 nM for HIR-A, HIR-B, and human insulin-like growth factor I receptor (HIGF-IR) in SPA-assay, respectively .

HY-P2093B

S961 acetate 5 Publications Verification	Insulin Receptor	Metabolic Disease
S961 acetate is an high-affinity and selective insulin receptor (IR) antagonist with IC₅₀s of 0.048, 0.027, and 630 nM for HIR-A, HIR-B, and human insulin-like growth factor I receptor (HIGF-IR) in SPA-assay, respectively .

HY-P2093A

S961 TFA	Insulin Receptor	Metabolic Disease
S961 TFA is an high-affinity and selective insulin receptor (IR) antagonist with IC₅₀s of 0.048, 0.027, and 630 nM for HIR-A, HIR-B, and human insulin-like growth factor I receptor (HIGF-IR) in SPA-assay, respectively .

HY-10555

AMG-221	11β-HSD	Metabolic Disease
AMG-221 is an inhibitor of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) with a K_i of 12.8 nM in vitro biochemical scintillation proximity assay (SPA) and an IC₅₀ of 10.1 nM in cell-based assays . AMG-221 can be used for the research of type 2 diabetes .

HY-147366

RBP4 ligand-1	Lipocalin Family	Metabolic Disease
RBP4 ligand-1 is a non-retinoid ligands for (RBP4) retinol-binding protein 4. The hRBP4_SPA IC₅₀ and RBP4-TTR FRET IC₅₀ values are 0.23±0.11 and 0.13±0.12 μM in the radioligand binding assay and FRET assay, respectively .

HY-128338

CETP-IN-3	CETP	Cardiovascular Disease
CETP-IN-3 (Compound 13) is an small molecule inhibitor of the plasma glycoprotein cholesterol ester transfer protein (CETP), elevating HDL-C through inhibition of CETP. CETP-IN-3 for the CETP inhibitory activity in the scintillation proximity (SPA) and whole plasma assay (WPA) with IC₅₀s of 0.002 μM and 0.06 μM, respectively .

HY-148860

NVP-DFF332 HIF-2α-IN-8	HIF/HIF Prolyl-Hydroxylase	Cancer
HIF-2α-IN-8 is a potent and orally active HIF2α inhibitor with IC₅₀ values of 9, 37, 246 nM for HIF2α SPA, HIF2α iScript, HIF2α HRE RGA, respectively. HIF-2α-IN-8 shows antitumor activity .

HY-156112

LM2I	Ser/Thr Protease	Cancer
LM2I is a derivative of Spinosyn A (SPA). LM2I is argininosuccinate synthase (ASS1) enzyme activator, and tumor inhibitor that directly interact with ASS1. LM2I has significant antiproliferative activity in seven colorectal cancer cell-lines and xenograft tumors of colorectal cancer. LM2I inhibits colorectal cancer cell growth via the EGFR pathway .

Cat. No.	Product Name	Type

HY-NP006

Protein A SPA	Native Proteins
Protein A (SPA) is an immunoglobulin (Ig) binding protein that exists on the surface of bacteria and can be freely secreted into the extracellular environment. Protein A blocks opsonization and phagocytosis and induces B-cell death in vitro by binding to the Fc region of antibodies and the Fab region of B-cell receptors. Protein A has the ability to inhibit opsonization and phagocytosis in vitro .

Protein A

SPA

Native Proteins

Protein A (SPA) is an immunoglobulin (Ig) binding protein that exists on the surface of bacteria and can be freely secreted into the extracellular environment. Protein A blocks opsonization and phagocytosis and induces B-cell death in vitro by binding to the Fc region of antibodies and the Fab region of B-cell receptors. Protein A has the ability to inhibit opsonization and phagocytosis in vitro .

Cat. No.	Product Name	Target	Research Area

HY-P2093

S961 5 Publications Verification	Insulin Receptor	Metabolic Disease
S961 is an high-affinity and selective insulin receptor (IR) antagonist with IC₅₀s of 0.048, 0.027, and 630 nM for HIR-A, HIR-B, and human insulin-like growth factor I receptor (HIGF-IR) in SPA-assay, respectively .

HY-P2093B

S961 acetate 5 Publications Verification	Insulin Receptor	Metabolic Disease
S961 acetate is an high-affinity and selective insulin receptor (IR) antagonist with IC₅₀s of 0.048, 0.027, and 630 nM for HIR-A, HIR-B, and human insulin-like growth factor I receptor (HIGF-IR) in SPA-assay, respectively .

HY-P10354

SPA4	Interleukin Related	Inflammation/Immunology
SPA4 is a TLR4-interacting peptide. SPA4 inhibits the LPS-induced TNF-α cytokine response without effect the cell viability or size .

HY-P2093A

S961 TFA	Insulin Receptor	Metabolic Disease
S961 TFA is an high-affinity and selective insulin receptor (IR) antagonist with IC₅₀s of 0.048, 0.027, and 630 nM for HIR-A, HIR-B, and human insulin-like growth factor I receptor (HIGF-IR) in SPA-assay, respectively .

Cat. No.	Product Name	Target	Research Area

HY-P99770

Omodenbamab 514-G3	Bacterial	Infection
Omodenbamab is an anti-SpA (Staphylococcal protein A) human monoclonal antibody with a K_D value of 0.0467 nM. Omodenbamab circumvents a key S. aureus evasion mechanism by targeting the cell wall moiety Protein A (SpA). Omodenbamab can be used in research of S. aureus bloodstream infection .

HY-P99477

Bevifimod PRTX-100	Inhibitory Antibodies	Cardiovascular Disease Inflammation/Immunology
Bevifimod (PRTX-100) is a highly purified form of Staphylococcal protein A (SpA). Bevifimod can be used for idiopathic thrombocytopenic purpura (ITP) research .

Species:	Human (2) Mouse (1)
Tag:	His (3) Avi (1)
Source:	HEK293 (1) E. coli (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P701069

	SP-17 Protein, Human (His) SPerm surface protein SP17; CT22; SP17-1; SPerm protein 17; SPA17;	Human	E. coli
	The SP-17 protein is an important sperm surface-binding protein that promotes high-affinity sperm attachment to the zona pellucida, indicating its critical role in fertilization. It is involved in the binding of the zona pellucida and carbohydrates, emphasizing its importance in the fertilization process. SP-17 Protein, Human (His) is the recombinant human-derived SP-17 protein, expressed by E. coli , with N-His labeled tag.

HY-P701070

	SP-17 Protein, Mouse (His) SPerm surface protein SP17; CT22; SP17-1; SPerm protein 17; SPA17	Mouse	E. coli
	SP-17 protein acts as a sperm surface zona pellucida binding protein, facilitating high-affinity spermatozoa binding to the zona pellucida.It potentially engages in binding interactions with zona pellucida and carbohydrates.Existing as a homodimer, SP-17 may interact with ROPN1, suggesting a cooperative role in sperm-egg interactions and fertilization processes.SP-17 Protein, Mouse (His) is the recombinant mouse-derived SP-17 protein, expressed by E.coli , with N-His labeled tag.

HY-P78098

	CD93/C1qR1 Protein, Human (Biotinylated, HEK293, His-Avi) C1q/MBL/SPA receptor; C1qR; C1qR(p); C1qRp; CDw93; CD93; C1QR1; MXRA4; ECSM3; dJ737E23.1	Human	HEK293
	The CD93/C1qR1 protein is thought to be a receptor or part of a larger complex and plays a crucial role in immune recognition by binding to C1q, mannose-binding lectin (MBL2), and pulmonary surfactant protein A (SPA) .Its interaction with these immune factors suggests a role in coordinating the innate immune response.CD93/C1qR1 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived CD93/C1qR1 protein, expressed by HEK293 , with C-Avi, C-His labeled tag.

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