LIV-1/SLC39A6 Protein, Mouse (HEK293, His)

The LIV-1/SLC39A6 protein is a zinc influx transporter that maintains zinc homeostasis and induces epithelial-mesenchymal transition (EMT). This heterodimer cooperates with SLC39A10 to trigger EMT, control NCAM1 phosphorylation and downregulate adhesion genes such as E-cadherin. LIV-1/SLC39A6 Protein, Mouse (HEK293, His) is the recombinant mouse-derived LIV-1/SLC39A6 protein, expressed by HEK293 , with C-His labeled tag. The total length of LIV-1/SLC39A6 Protein, Mouse (HEK293, His) is 315 a.a., with molecular weight of 60-80 kDa.

LIV-1/SLC39A6 Protein is a zinc-influx transporter involved in zinc homeostasis and the induction of epithelial-to-mesenchymal transition (EMT). When combined with SLC39A10, the heterodimer formed by SLC39A10 and SLC39A6 facilitates cellular zinc uptake, triggering EMT and controlling NCAM1 phosphorylation during this process. Zinc influx inactivates GSK3B, leading to the down-regulation of adherence genes such as E-cadherin, resulting in the loss of cell adherence. Additionally, the SLC39A10-SLC39A6 heterodimer plays a vital role in initiating mitosis by importing zinc into cells, initiating a pathway that leads to the onset of mitosis. It also contributes to T-cell receptor signaling regulation by mediating zinc uptake into activated lymphocytes and regulates zinc influx necessary for proper meiotic progression to metaphase II (MII), facilitating the oocyte-to-egg transition.

Mouse

HEK293

C-His

Q8C145 (L21-W335)

106957  [NCBI]

60-80 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.