2. PROTAC Epigenetics
  3. PROTACs Epigenetic Reader Domain
  4. PROTAC BRD4 Degrader-30

PROTAC BRD4 degrader-30 is an ISOX-DUAL-Based PROTAC degrader selectively targeting BRD4 (IC50 = 65 nM). PROTAC BRD4 degrader-30 can be used for research of c-Myc oncoprotein and cancer cell pathophysiology. (Pink: BRD4 ligand (HY-172828); Blue: CRBN ligand (HY-103596); Black: linker (HY-Y0139); CRBN ligand+linker: HY-138847).

For research use only. We do not sell to patients.

PROTAC BRD4 Degrader-30 Chemical Structure

PROTAC BRD4 Degrader-30 Chemical Structure

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PROTAC BRD4 Degrader-30 Related Antibodies

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Description

PROTAC BRD4 degrader-30 is an ISOX-DUAL-Based PROTAC degrader selectively targeting BRD4 (IC50 = 65 nM). PROTAC BRD4 degrader-30 can be used for research of c-Myc oncoprotein and cancer cell pathophysiology. (Pink: BRD4 ligand (HY-172828); Blue: CRBN ligand (HY-103596); Black: linker (HY-Y0139); CRBN ligand+linker: HY-138847)[1].

IC50 & Target[1]

BRD4

65 nM (IC50)

In Vitro

PROTAC BRD4 degrader-30 (40 nM-40 μM, 15 min) shows no observable ubiquitination for the degraders with shorter linkers[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PROTAC BRD4 Degrader-30 Related Antibodies
Molecular Weight

902.05

Formula

C49H59N9O8
SMILES

CC1=NOC(C)=C1C2=CC=C(N(CCN3CCN(CC(NCCCOC4=C(C(N(C5CCC(NC5=O)=O)C6=O)=O)C6=CC=C4)=O)CC3)C(CCC7=CC=C(OCCCN(C)C)C=C7)=N8)C8=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PROTAC BRD4 Degrader-30 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC BRD4 Degrader-30PROTACsEpigenetic Reader DomainCRBNISOX-DUALdegraderc-MyccancerInhibitorinhibitorinhibit

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