2. GPCR/G Protein Apoptosis Others
  3. Taste Receptor Apoptosis Drug Derivative
  4. Neotame (GMP Like)

Neotame (GMP Like) is the GMP Like class Neotame (HY-W011053) that can be used as pharmaceutical excipients. Neotame is a derivative of Aspartame (HY-B0361) and is a flavor enhancer and low-caloric, non-nutritive, high-intensity artificial sweetener that is 7000-13,000 times sweeter than sugar. Neotame causes intestinal epithelial cell death at high concentrations. Neotame induces Apoptosis of Caco-2 cells.

For research use only. We do not sell to patients.

Neotame (GMP Like) Chemical Structure

Neotame (GMP Like) Chemical Structure

CAS No. : 165450-17-9

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Other Forms of Neotame (GMP Like):

Neotame (GMP Like) Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Neotame (GMP Like) is the GMP Like class Neotame (HY-W011053) that can be used as pharmaceutical excipients. Neotame is a derivative of Aspartame (HY-B0361) and is a flavor enhancer and low-caloric, non-nutritive, high-intensity artificial sweetener that is 7000-13,000 times sweeter than sugar. Neotame causes intestinal epithelial cell death at high concentrations. Neotame induces Apoptosis of Caco-2 cells[1][2][3].

In Vitro

Neotame (GMP Like) (100 μM and higher, 6-24 h) causes intestinal epithelial cell death at high concentrations and leak across the epithelial monolayer at lower concentrations (1-100 μM)[3].
Neotame (GMP Like) (0-1000 μM and higher, 6-24 h)-induced damage to the intestinal epithelium in vitro, both barrier disruption and cell death via apoptosis, is mediated by the sweet taste receptor, T1R3[3] .
Neotame (GMP Like) (0-100 μM, 24 h) reduces Claudin 3 expression observed at Caco-2 cell surface[3] .
6 h Increased cell death from 100 μM and higher.
Increased significant apoptosis of Caco-2 cells from 10 μM and higher.
0, 10, 100 μM 24 h Reduced Claudin 3 expression observed at Caco-2 cell surface.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Neotame (GMP Like) Related Antibodies

Cell Viability Assay[3]

Cell Line: Caco-2 cells
Concentration: 0, 0.01, 0.1, 1, 10, 100, 1000, 10000 μM
Incubation Time: 24 h
Result: Showed very little cell viability at high concentrations.

Apoptosis Analysis[3]

Cell Line: Caco-2 cells
Concentration: 0, 0.01, 0.1, 1, 10, 100, 1000, 10000 μM
Incubation Time: 6 h
Result: Increased cell death from 100 μM and higher.
Increased significant apoptosis of Caco-2 cells from 10 μM and higher.

Western Blot Analysis[3]

Cell Line: Caco-2 cells
Concentration: 0, 10, 100 μM
Incubation Time: 24 h
Result: Reduced Claudin 3 expression observed at Caco-2 cell surface.
In Vivo

Neotame (GMP Like) (0.75 mg/kg, p.o., daily, 4 weeks) consumption perturbs the diversities as well as the community compositions of gut microbiome and alters metabolite profiles in fecal samples of male CD-1 mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Ten male CD-1 mice around 7 weeks old[1].
Dosage: 0.75 mg/kg
Administration: p.o., daily, 4 weeks
Result: Induced lower alpha-diversity of gut microbiome than the control group.
Enriched phylum Bacteroidetes, while decreased Firmicutes.
Induced multiple components of family Lachnospiraceae and family Ruminococcaceae lower than controls, such as Blautia, Dorea, Oscillospira and Ruminococcus.
Enriched amino acid metabolism, LPS biosynthesis, antibiotics biosynthesis and folate biosynthesis pathways.
Induced lower fatty acid metabolism, carbohydrate metabolism, lipid metabolism and ABC transporters than in controls.
Decreased most of the altered metabolites, such as malic acid, mannose-6-phosphate, 5-aminovaleric acid and glyceric acid.
Decreased most of the identified lipids and fatty acids, including 1,3-dipalmitate, 1-monopalmitin, linoleic acid and stearic acid.
Increased the concentrations of cholesterol, campesterol and stigmastanol in the fecal samples.
Molecular Weight

378.46

Formula

C20H30N2O5
CAS No.
SMILES

COC([C@H](CC1=CC=CC=C1)NC([C@H](CC(O)=O)NCCC(C)(C)C)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Neotame (GMP Like) Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Neotame (GMP Like)165450-17-9Taste ReceptorApoptosisDrug DerivativeDrug derivativeInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Neotame (GMP Like)
Cat. No.:
HY-W011053GL
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.