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Results for "

menthol

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Biochemical Assay Reagents (2) Calcium Channel (2) Drug Derivative (1) Drug Intermediate (1) Drug Metabolite (2) Endogenous Metabolite (3) Fungal (2) GABA Receptor (2) Isotope-Labeled Compounds (4) Reference Standards (4) TRP Channel (7)
By Research Areas:	Cancer (5) Infection (1) Inflammation/Immunology (1) Neurological Disease (7)
Oligonucleotides:	Flavoring Agents (1)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-75161

(-)-Menthol 1 Publications Verification	TRP Channel Endogenous Metabolite	Cancer
(-)-Menthol is a key component of peppermint oil that binds and activates transient receptor potential melastatin 8 (TRPM8), a Ca ²⁺-permeable nonselective cation channel, to increase [Ca ²⁺]_i . Antitumor activity .

HY-122317

Menthol glucuronide	Drug Metabolite	Others
Menthol glucuronide, a metabolite of Menthol (HY-N1369), is a plasma and urine biomarker of acute Menthol inhalation .

HY-75161R

*(-)-Menthol* (Standard)**	Reference Standards TRP Channel Endogenous Metabolite	Cancer
(-)-Menthol (Standard) is the analytical standard of (-)-Menthol. This product is intended for research and analytical applications. (-)-Menthol is a key component of peppermint oil that binds and activates transient receptor potential melastatin 8 (TRPM8), a Ca2+-permeable nonselective cation channel, to increase [Ca2+]i . Antitumor activity .

HY-W017277

(+)-Menthol D-menthol	Fungal	Neurological Disease
(+)-Menthol (D-Menthol) is one of the optical isomers of Menthol. (+)-Menthol can reduce the electrically evoked contractions of rat phrenic hemidiaphragm in vitro. Local anaesthetic activity. (+)-Menthol inhibits fungal growth and sporulation. (+)-Menthol can also inhibit the growth of Microcystis aeruginosa cells .

HY-Y1683

DL-Menthol Racementhol	GABA Receptor	Neurological Disease
DL-Menthol (Racementhol) is an orally active, GABA_aR positive allosteric modulator and UDP-glucuronosyltransferase (UGT) inhibitor that can cross the blood-brain barrier. DL-Menthol binds to GABA_AR and exhibits an allosteric activation effect, enhancing GABA-mediated chloride influx and inhibiting neuronal excitability. DL-Menthol can induce surgical anesthesia in fish and inhibit the metabolic detoxification of tobacco carcinogens by human liver and intestinal UGT enzymes, resulting in reduced NNAL-N-Gluc production .

HY-N1369S

Menthol-d4	Isotope-Labeled Compounds Calcium Channel	Neurological Disease
Menthol-d₄ is the deuterium labeled Menthol. Menthol is a natural analgesic compound. Menthol could cause a feeling of coolness due to stimulation of ‘cold’ receptors by inhibiting Ca++ currents of neuronal membranes .

HY-N1369S1

Menthol-d2	Calcium Channel Isotope-Labeled Compounds	Neurological Disease
Menthol-d₂ is deuterated labeled Menthol (HY-N1369). Menthol is an analgesic and TRPM8 modulator. TRPM8 is a cold temperature sensing ion channel, and Menthol can regulate TRPM8 to exert analgesic and anti-irritation mechanisms. Menthol stimulates cold receptors and produces a cooling sensation by inhibiting Ca++ currents in neuronal cell membranes .

HY-W711474

*(-)-Menthol-d4*	Isotope-Labeled Compounds TRP Channel Endogenous Metabolite	Cancer
(-)-Menthol-d₄ is the deuterium labeled (-)-Menthol (HY-75161). (-)-Menthol is a key component of peppermint oil that binds and activates transient receptor potential melastatin 8 (TRPM8), a Ca2+-permeable nonselective cation channel, to increase [Ca2+]i . Antitumor activity .

HY-W017277R

*(+)-Menthol* (Standard)** D-menthol (Standard)	Fungal Reference Standards	Infection Neurological Disease
(+)-Menthol (Standard) is the analytical standard of (+)-Menthol. This product is intended for research and analytical applications. (+)-Menthol (D-Menthol) is one of the optical isomers of Menthol. (+)-Menthol can reduce the electrically evoked contractions of rat phrenic hemidiaphragm in vitro. Local anaesthetic activity. (+)-Menthol inhibits fungal growth and sporulation. (+)-Menthol can also inhibit the growth of Microcystis aeruginosa cells .

HY-Y1683R

*DL-Menthol* (Standard)** Racementhol (Standard)	Reference Standards GABA Receptor	Others
DL-Menthol (Standard) is the analytical standard of DL-Menthol. This product is intended for research and analytical applications. DL-Menthol is a relative configuration of (-)-Menthol. DL-Menthol relates to the activation of GABAA receptor .

HY-W087207

*Loxoprofen L-menthol* ester**	Drug Derivative	Inflammation/Immunology
Loxoprofen L-menthol ester is a degradation product Loxoprofen sodium (HY-B0578A). Loxoprofen sodium is a non-steroidal, orally active anti-inflammatory agent with analgesic and anti-pyretic properties .

HY-135186

L-Monomenthyl glutarate	Biochemical Assay Reagents	Others
L-Monomenthyl glutarate is a menthol coolant. L-Monomenthyl glutarate has a strong volatility and permeability, high concentration of menthol vapor has a strong irritation and erosion effect on human skin and mucosa. L-Monomenthyl glutarate can be used in food, tobacco and other daily chemical products .

HY-N9484S

Menthofuran-13C2	Drug Metabolite Isotope-Labeled Compounds	Others
Menthofuran- ¹³C₂ is ¹³C labeled Menthol (HY-N1369). Menthol is an analgesic and TRPM8 modulator. TRPM8 is a cold temperature sensing ion channel, and Menthol can regulate TRPM8 to exert analgesic and anti-irritation mechanisms. Menthol stimulates cold receptors and produces a cooling sensation by inhibiting Ca ⁺⁺ currents in neuronal cell membranes. Menthol also improves oral nicotine rejection in mice .

HY-W683864

Menthyl isovalerate	Drug Intermediate	Others
Menthyl isovalerate is an ester formed by menthol and isovaleric acid. Menthyl isovalerate can be used as a food additive for flavor and fragrance .

HY-N7132

Menthyl acetate L-Menthyl acetate; (-)-Menthyl acetate	Others	Others
Menthyl acetate (L-Menthyl acetate) is a derivative of L-menthol. Menthyl acetate is effective to enhance 5-aminolevulinic acid (ALA) skin permeation .

HY-N7132R

Menthyl acetate (Standard) L-Menthyl acetate (Standard); (-)-Menthyl acetate (Standard)	Reference Standards Others	Others
Menthyl acetate (Standard) is the analytical standard of Menthyl acetate. This product is intended for research and analytical applications. ?Menthyl acetate (L-Menthyl acetate) is a derivative of L-menthol. ?Menthyl acetate is effective to enhance 5-aminolevulinic acid (ALA) skin permeation .

HY-108449

Acoltremon 1 Publications Verification WS-12; AR-15512; AVX-012	TRP Channel	Cancer
Acoltremon (WS-12; AR-15512) is a potent and selective TRPM8 agonist, the menthol derivative, as a cooling agent. Acoltremon shows analgesic effect, and can be used in chronic neuropathic pain research .

HY-18662

RQ-00203078 4 Publications Verification	TRP Channel	Neurological Disease Cancer
RQ-00203078 is a highly selective, potent and orally active TRPM8 antagonist with IC₅₀s of 5.3 nM and 8.3 nM for rat and human TRPM8 channels, respectively. RQ-00203078 shows little inhibitory action against TRPV1, TRPA1, TRPV4, or TRPM2 channels .

HY-W317408

(+)-Menthyl acetate	Biochemical Assay Reagents	Others
(+)-Menthyl acetate is a compound isolated from natural Cunila angustifolia Benth essential oil. The selectivity of (+)-Menthyl acetate is higher than that of MCF-7 cell line, IC₅₀=34.0 μg?mL ^-1, and lower than that of SK-Mel-28 cell line, IC₅₀=279.9 μg?mL ^-1, on A549 cell without fatal .

HY-115506

PF-05105679	TRP Channel	Neurological Disease
PF-05105679 is an orally active and selective TRPM8 antagonist with an IC₅₀ of 103 nM. PF-05105679 has the potential for cold-related pain .

HY-N7536

Voacangine	TRP Channel	Others
Voacangine is an antagonist for TRPV1 and TRPM8 but as an agonist for TRPA1 (EC₅₀=8 μM). Voacangine competitively blockes capsaicin binding to TRPV1 (IC₅₀=50 μM). Voacangine competitively inhibits the binding of menthol to TRPM8 (IC₅₀=9 μM) and it shows noncompetitive inhibition against icilin (IC₅₀=7 μM). Voacangine selectively abrogates chemical agonist-induced TRPM8 activation and did not affect cold-induced activation. Voacangine is an alkaloid isolated from the root bark of Voacanga africana .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-75161

(-)-Menthol 1 Publications Verification	Structural Classification Natural Products Classification of Application Fields Labiatae Source classification Erythrina poeppigiana Plants Endogenous metabolite Disease Research Fields Cancer	TRP Channel Endogenous Metabolite
(-)-Menthol is a key component of peppermint oil that binds and activates transient receptor potential melastatin 8 (TRPM8), a Ca ²⁺-permeable nonselective cation channel, to increase [Ca ²⁺]_i . Antitumor activity .

HY-75161R

*(-)-Menthol* (Standard)**	Structural Classification Other Monoterpenes Human Gut Microbiota Metabolites Microorganisms Terpenoids Labiatae Source classification Erythrina poeppigiana Plants Endogenous metabolite	Reference Standards TRP Channel Endogenous Metabolite
(-)-Menthol (Standard) is the analytical standard of (-)-Menthol. This product is intended for research and analytical applications. (-)-Menthol is a key component of peppermint oil that binds and activates transient receptor potential melastatin 8 (TRPM8), a Ca2+-permeable nonselective cation channel, to increase [Ca2+]i . Antitumor activity .

HY-W017277

(+)-Menthol D-menthol	Natural Products Labiatae Source classification Erythrina poeppigiana Plants	Fungal
(+)-Menthol (D-Menthol) is one of the optical isomers of Menthol. (+)-Menthol can reduce the electrically evoked contractions of rat phrenic hemidiaphragm in vitro. Local anaesthetic activity. (+)-Menthol inhibits fungal growth and sporulation. (+)-Menthol can also inhibit the growth of Microcystis aeruginosa cells .

HY-Y1683

DL-Menthol Racementhol	Structural Classification Natural Products Classification of Application Fields Leguminosae Labiatae Source classification Other Diseases Erythrina poeppigiana Plants Glycyrrhiza uralensis Fisch. Disease Research Fields	GABA Receptor
DL-Menthol (Racementhol) is an orally active, GABA_aR positive allosteric modulator and UDP-glucuronosyltransferase (UGT) inhibitor that can cross the blood-brain barrier. DL-Menthol binds to GABA_AR and exhibits an allosteric activation effect, enhancing GABA-mediated chloride influx and inhibiting neuronal excitability. DL-Menthol can induce surgical anesthesia in fish and inhibit the metabolic detoxification of tobacco carcinogens by human liver and intestinal UGT enzymes, resulting in reduced NNAL-N-Gluc production .

HY-N7132

Menthyl acetate L-Menthyl acetate; (-)-Menthyl acetate	Structural Classification Natural Products Classification of Application Fields Acacia farnesiana (Linn.) Willd. Labiatae Source classification Other Diseases Plants Disease Research Fields	Others
Menthyl acetate (L-Menthyl acetate) is a derivative of L-menthol. Menthyl acetate is effective to enhance 5-aminolevulinic acid (ALA) skin permeation .

HY-N7536

Voacangine	Alkaloids Structural Classification other families Classification of Application Fields Source classification Other Diseases Plants Disease Research Fields Indole Alkaloids	TRP Channel
Voacangine is an antagonist for TRPV1 and TRPM8 but as an agonist for TRPA1 (EC₅₀=8 μM). Voacangine competitively blockes capsaicin binding to TRPV1 (IC₅₀=50 μM). Voacangine competitively inhibits the binding of menthol to TRPM8 (IC₅₀=9 μM) and it shows noncompetitive inhibition against icilin (IC₅₀=7 μM). Voacangine selectively abrogates chemical agonist-induced TRPM8 activation and did not affect cold-induced activation. Voacangine is an alkaloid isolated from the root bark of Voacanga africana .

HY-W017277R

*(+)-Menthol* (Standard)** D-menthol (Standard)	Natural Products Labiatae Source classification Erythrina poeppigiana Plants	Fungal Reference Standards
(+)-Menthol (Standard) is the analytical standard of (+)-Menthol. This product is intended for research and analytical applications. (+)-Menthol (D-Menthol) is one of the optical isomers of Menthol. (+)-Menthol can reduce the electrically evoked contractions of rat phrenic hemidiaphragm in vitro. Local anaesthetic activity. (+)-Menthol inhibits fungal growth and sporulation. (+)-Menthol can also inhibit the growth of Microcystis aeruginosa cells .

HY-Y1683R

*DL-Menthol* (Standard)** Racementhol (Standard)	Structural Classification Natural Products Leguminosae Labiatae Source classification Erythrina poeppigiana Plants Glycyrrhiza uralensis Fisch.	Reference Standards GABA Receptor
DL-Menthol (Standard) is the analytical standard of DL-Menthol. This product is intended for research and analytical applications. DL-Menthol is a relative configuration of (-)-Menthol. DL-Menthol relates to the activation of GABAA receptor .

HY-N7132R

Menthyl acetate (Standard) L-Menthyl acetate (Standard); (-)-Menthyl acetate (Standard)	Structural Classification Natural Products Acacia farnesiana (Linn.) Willd. Labiatae Source classification Plants	Reference Standards Others
Menthyl acetate (Standard) is the analytical standard of Menthyl acetate. This product is intended for research and analytical applications. ?Menthyl acetate (L-Menthyl acetate) is a derivative of L-menthol. ?Menthyl acetate is effective to enhance 5-aminolevulinic acid (ALA) skin permeation .

Cat. No.	Product Name	Chemical Structure

HY-N1369S

Menthol-d4
Menthol-d₄ is the deuterium labeled Menthol. Menthol is a natural analgesic compound. Menthol could cause a feeling of coolness due to stimulation of ‘cold’ receptors by inhibiting Ca++ currents of neuronal membranes .

HY-N1369S1

Menthol-d2
Menthol-d₂ is deuterated labeled Menthol (HY-N1369). Menthol is an analgesic and TRPM8 modulator. TRPM8 is a cold temperature sensing ion channel, and Menthol can regulate TRPM8 to exert analgesic and anti-irritation mechanisms. Menthol stimulates cold receptors and produces a cooling sensation by inhibiting Ca++ currents in neuronal cell membranes .

HY-W711474

*(-)-Menthol-d4*
(-)-Menthol-d₄ is the deuterium labeled (-)-Menthol (HY-75161). (-)-Menthol is a key component of peppermint oil that binds and activates transient receptor potential melastatin 8 (TRPM8), a Ca2+-permeable nonselective cation channel, to increase [Ca2+]i . Antitumor activity .

HY-N9484S

Menthofuran-13C2
Menthofuran- ¹³C₂ is ¹³C labeled Menthol (HY-N1369). Menthol is an analgesic and TRPM8 modulator. TRPM8 is a cold temperature sensing ion channel, and Menthol can regulate TRPM8 to exert analgesic and anti-irritation mechanisms. Menthol stimulates cold receptors and produces a cooling sensation by inhibiting Ca ⁺⁺ currents in neuronal cell membranes. Menthol also improves oral nicotine rejection in mice .

Menthofuran-13C2

Menthofuran- ¹³C₂ is ¹³C labeled Menthol (HY-N1369). Menthol is an analgesic and TRPM8 modulator. TRPM8 is a cold temperature sensing ion channel, and Menthol can regulate TRPM8 to exert analgesic and anti-irritation mechanisms. Menthol stimulates cold receptors and produces a cooling sensation by inhibiting Ca ⁺⁺ currents in neuronal cell membranes. Menthol also improves oral nicotine rejection in mice .

Cat. No.	Product Name		Classification

HY-75161

(-)-Menthol 1 Publications Verification		Flavoring Agents
(-)-Menthol is a key component of peppermint oil that binds and activates transient receptor potential melastatin 8 (TRPM8), a Ca ²⁺-permeable nonselective cation channel, to increase [Ca ²⁺]_i . Antitumor activity .

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menthol

Inhibitors & Agonists

NaturalProducts

Isotope-Labeled Compounds

Oligonucleotides

Natural
Products