2. Academic Validation
  3. Antiviral activity of 5,6,7-trimethoxyflavone and its potentiation of the antiherpes activity of acyclovir

Antiviral activity of 5,6,7-trimethoxyflavone and its potentiation of the antiherpes activity of acyclovir

  • J Antimicrob Chemother. 1997 Jun;39(6):821-4. doi: 10.1093/jac/39.6.821.
K Hayashi 1,  T Hayashi,  H Otsuka,  Y Takeda
Affiliations

Affiliation

  • 1 Department of Virology, Toyama Medical and Pharmaceutical University, Sugitani, Japan.
PMID: 9222055 DOI: 10.1093/jac/39.6.821
Abstract

A naturally occurring flavone, 5,6,7-trimethoxyflavone (TMF), isolated from the plant Callicarpa japonica, was subjected to Antiviral assays. The compound exhibited relatively high inhibitory effects on herpes simplex virus type 1 (HSV-1), human cytomegalovirus and poliovirus. The anti-HSV-1 action was not due to the inhibition of virus adsorption, entry and viral protein synthesis, but might involve, at least in part, a virucidal activity, which results in a suppression of viral binding to host cells at an early replication stage. TMF and acylovir were synergic in their anti-HSV activities at levels below the 50% inhibitory concentrations for Antiviral activity.

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