2. Academic Validation
  3. Inhibitory effect of arphamenine A on intestinal dipeptide transport

Inhibitory effect of arphamenine A on intestinal dipeptide transport

  • Biosci Biotechnol Biochem. 1996 Nov;60(11):1893-5. doi: 10.1271/bbb.60.1893.
M Enjoh 1,  K Hashimoto,  S Arai,  M Shimizu
Affiliations

Affiliation

  • 1 Department of Applied Biological Chemistry, Graduate School of Agriculture and Life Sciences, University of Tokyo, Japan.
PMID: 8987870 DOI: 10.1271/bbb.60.1893
Abstract

Arphamenine A, an Arg-Phe analog without a peptide bond, has been reported to be a possible inhibitor of the peptide transporter [H. Daniel and S.A. Adibi, FASEB J., 8, 753 (1994)]. The present study demonstrated that arphamenine A is not a real inhibitor, but is a substrate for the transporter, being transported transepithelially under a proton gradient. The substrate specificity of the peptide transporter was wider than expected.

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