2. Academic Validation
  3. Antiallergy activity of substituted 11-oxo-11 H-pyrido[2,1-b]quinazoline-8-carboxylic acids

Antiallergy activity of substituted 11-oxo-11 H-pyrido[2,1-b]quinazoline-8-carboxylic acids

  • J Med Chem. 1979 Jun;22(6):748-50. doi: 10.1021/jm00192a027.
C F Schwender,  B R Sunday,  D J Herzig,  E K Kusner,  P R Schumann,  D L Gawlak
PMID: 88523 DOI: 10.1021/jm00192a027
Abstract

A series of substituted 11-oxo-11H-pyrido[2,1-b]quinazoline-8-carboxylic acids were prepared and evaluated as antiallergy agents. Several analogues were orally active. 2-Methyl-11-oxo-11H-pyrido[2,1-b]quinoazoline-8-carboxylic acid (6) was superior to cromolyn sodium and doxantrazole orally and intravenously in the rat PCA test and a rat allergic bronchospasm model.

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