2. Academic Validation
  3. Potential antiviral effects of the marine probiotic Paraliobacillus zengyii on the respiratory syncytial virus

Potential antiviral effects of the marine probiotic Paraliobacillus zengyii on the respiratory syncytial virus

  • mLife. 2025 Jun 18;4(3):249-258. doi: 10.1002/mlf2.70015.
Qianjin Fan 1 2,  Beijie Li 2 3,  Lan Chen 2 3,  Mengqi Jiao 2,  Zhijie Cao 2,  Kun Yue 2 4,  Haoyue Huangfu 1 2,  Hui Sun 2,  Xiaoxia Wang 5,  Xuelian Luo 2 3,  Jianguo Xu 1 2 3 4
Affiliations

Affiliations

  • 1 School of Medicine, Institute of Public Health, Nankai University Tianjin China.
  • 2 National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, Chinese Center for Disease Control and Prevention, National Institute for Communicable Disease Control and Prevention Beijing China.
  • 3 Center of Reverse Microbial Etiology, School of Public Health, Shanxi Medical University Taiyuan China.
  • 4 Research Unite for Unknown Microbe, Chinese Academy of Medical Sciences & Peking Union Medical College Beijing China.
  • 5 Clinical & Central Laboratory of Sanya People's Hospital Sanya China.
PMID: 40600055 DOI: 10.1002/mlf2.70015
Abstract

Probiotics can reduce the incidence of respiratory syncytial virus (RSV) disease in premature infants; this approach is resource-intensive and less expensive than Other strategies and easier to implement than most current methods worldwide. Traditional lactic acid-producing bacteria are the main probiotics that have been studied for RSV treatment. Marine probiotics promote the survival, immunity, and disease resistance of aquatic Plants and Animals. However, relatively little research has been conducted on viral infections in humans. Here, we report a slightly halophilic and extremely halotolerant marine bacterium, Paraliobacillus zengyii, which has Antiviral activity and grows at a relatively low temperature (28°C). We found that P. zengyii inhibited RSV Infection by regulating the interferon (IFN) response both in vitro and in vivo. P. zengyii significantly increased the RSV-induced phosphorylation of TBK1 and IRF3 and the expression of Antiviral factors interferon-induced transmembrane protein 1 (IFITM1) and interferon-induced transmembrane protein 3 (IFITM3). Furthermore, P. zengyii upregulated Sendai virus (SeV)- and poly(I:C)-induced IFN-β expression. These results indicate that the marine bacterium P. zengyii inhibits RSV Infection and increases IFN-β production in response to RSV, SeV Infection, or poly(I:C) stimulation. Consequently, P. zengyii has potential as a broad-spectrum anti-RNA virus probiotic.

Keywords

Paraliobacillus zengyii; antiviral activity; marine probiotics; respiratory syncytial virus; type I interferon.

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