2. Academic Validation
  3. Mechanistic Insights into Maltol-Mediated Reversal of Postmenopausal Osteoporosis via Regulation of CDK14 Ubiquitination in Macrophages

Mechanistic Insights into Maltol-Mediated Reversal of Postmenopausal Osteoporosis via Regulation of CDK14 Ubiquitination in Macrophages

  • J Agric Food Chem. 2025 May 14;73(19):11730-11755. doi: 10.1021/acs.jafc.5c00545.
Zhuoru Jin 1,  Yufei Wei 2,  Zimo Zhou 1,  Zheng Fan 1,  Ying Huang 3,  Da Liu 1
Affiliations

Affiliations

  • 1 Department of Orthopedics, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, China.
  • 2 Department of Immunology, College of Basic Medical Sciences, China Medical University, Shenyang, Liaoning 110122, China.
  • 3 Department of Ultrasound, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, China.
PMID: 40315161 DOI: 10.1021/acs.jafc.5c00545
Abstract

Maltol, primarily derived from Korean red ginseng, exhibits anti-inflammatory properties by modulating macrophage polarization and has potential therapeutic effects on postmenopausal osteoporosis, a condition linked to inflammation. This study explored the molecular mechanisms underlying maltol's ability to inhibit M1 macrophage polarization and regulate osteoblast differentiation via macrophage-mediated pathways. Using in vitro and in vivo models, we demonstrated that maltol upregulates RNF213, which inhibits the CDK14-Pdgfrβ signaling pathway, suppressing M1 polarization and reducing NFκB phosphorylation and pro-inflammatory cytokine production. Additionally, maltol decreases TNFSF12 secretion, mitigating estrogen deficiency-induced osteoblast Apoptosis and promoting differentiation. These findings highlight maltol's potential in managing postmenopausal osteoporosis and Other inflammatory diseases.

Keywords

CDK14; TNFSF12; macrophage; maltol; osteoblast; osteoporosis.

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