2. Academic Validation
  3. Switching It up with New KRAS Inhibitors

Switching It up with New KRAS Inhibitors

  • J Med Chem. 2025 May 8;68(9):9126-9128. doi: 10.1021/acs.jmedchem.5c00998.
Alex G Waterson 1
Affiliations

Affiliation

  • 1 Departments of Pharmacology and Chemistry, Vanderbilt University School of Medicine, 2220 Pierce Avenue, Nashville, Tennessee 37232, United States.
PMID: 40261144 DOI: 10.1021/acs.jmedchem.5c00998
Abstract

Alongside significant recent advancements in drugging an historically notorious oncogene, scientists continue to uncover new ways to target KRAS. This viewpoint summarizes the newly reported discovery of a novel chemical template that features the ability to tailor inhibition to different activation states of nucleotide-bound KRAS from the same scaffold.

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