2. Academic Validation
  3. A Route to Synthesize Ionizable Lipid ALC-0315, a Key Component of the mRNA Vaccine Lipid Matrix

A Route to Synthesize Ionizable Lipid ALC-0315, a Key Component of the mRNA Vaccine Lipid Matrix

  • Russ J Bioorg Chem. 2023;49(2):412-415. doi: 10.1134/S1068162023020061.
I A Boldyrev 1,  V P Shendrikov 1 2,  A G Vostrova 1,  E L Vodovozova 1
Affiliations

Affiliations

  • 1 Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, Russia.
  • 2 Mendeleev University of Chemical Technology of Russia, 125047 Moscow, Russia.
PMID: 37252003 DOI: 10.1134/S1068162023020061
Abstract

The ionizable lipid ALC-0315, ((4-hydroxybutyl)azanediyl)bis(hexane-6,1-diyl)bis(2-hexyldecanoate), is a component of the lipid matrix of the prophylactic SARS-CoV-2 mRNA vaccine produced by Pfizer/BioNTech. This lipid ensures efficient vaccine assembly, protects the mRNA from premature degradation, and promotes the release of the nucleic acid into the cytoplasm for its further processing after endocytosis. The present work describes a simple and economical method for the synthesis of the ALC-0315 lipid, which can be taken advantage of in mRNA vaccine production.

Keywords

ALC-0315; ionizable lipid; lipid nanoparticles; mRNA; synthesis.

Figures
Products