2. Academic Validation
  3. Saccharobisindole, Neoasterric Methyl Ester, and 7-Chloro-4(1H)-quinolone: Three New Compounds Isolated from the Marine Bacterium Saccharomonospora sp

Saccharobisindole, Neoasterric Methyl Ester, and 7-Chloro-4(1H)-quinolone: Three New Compounds Isolated from the Marine Bacterium Saccharomonospora sp

  • Mar Drugs. 2021 Dec 29;20(1):35. doi: 10.3390/md20010035.
Sohee Kim 1,  Tu Cam Le 2 3,  Sang-Ah Han 1,  Prima F Hillman 4,  Ahreum Hong 1 5,  Sunghoon Hwang 6,  Young Eun Du 6,  Hiyoung Kim 7,  Dong-Chan Oh 6,  Sun-Shin Cha 4,  Jihye Lee 4 5,  Sang-Jip Nam 4,  William Fenical 8
Affiliations

Affiliations

  • 1 The Graduate School of Industrial Pharmaceutical Sciences, Ewha Womans University, Seoul 03760, Korea.
  • 2 Laboratory of Advanced Materials Chemistry, Advanced Institute of Materials Science, Ton Duc Thang University, Ho Chi Minh City 700000, Vietnam.
  • 3 Faculty of Applied Sciences, Ton Duc Thang University, Ho Chi Minh City 700000, Vietnam.
  • 4 Department of Chemistry and Nanoscience, Ewha Womans University, Seoul 03760, Korea.
  • 5 Laboratories of Marine New Drugs, REDONE Seoul, Seoul 08594, Korea.
  • 6 Natural Products Research Institute, College of Pharmacy, Seoul National University, Seoul 08826, Korea.
  • 7 Department of Biomedical Science and Engineering, Konkuk University, Seoul 05029, Korea.
  • 8 Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California-San Diego, La Jolla, CA 92093-0204, USA.
PMID: 35049890 DOI: 10.3390/md20010035
Abstract

Analysis of the chemical components from the culture broth of the marine bacterium Saccharomonospora sp. CNQ-490 has yielded three novel compounds: saccharobisindole (1), neoasterric methyl ester (2), and 7-chloro-4(1H)-quinolone (3), in addition to acremonidine E (4), pinselin (5), penicitrinon A (6), and penicitrinon E (7). The chemical structures of the three novel compounds were elucidated by the interpretation of 1D, 2D nuclear magnetic resonance (NMR), and high-resolution mass spectrometry (HRMS) data. Compound 2 generated weak inhibition activity against Bacillus subtilis KCTC2441 and Staphylococcus aureus KCTC1927 at concentrations of 32 μg/mL and 64 μg/mL, respectively, whereas compounds 1 and 3 did not have any observable effects. In addition, compound 2 displayed weak anti-quorum sensing (QS) effects against S. aureus KCTC1927 and Micrococcus luteus SCO560.

Keywords

Saccharomonospora sp.; antibacterial activity; marine natural products.

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