2. Academic Validation
  3. Unusual Bicyclo[3.2.1]Octanoid Neolignans from Leaves of Piper crocatum and Their Effect on Pyruvate Dehydrogenase Activity

Unusual Bicyclo[3.2.1]Octanoid Neolignans from Leaves of Piper crocatum and Their Effect on Pyruvate Dehydrogenase Activity

  • Plants (Basel). 2021 Sep 7;10(9):1855. doi: 10.3390/plants10091855.
Yu Juan Chai 1,  Younghoon Go 2,  Hai Qi Zhou 3,  Hong Xu Li 3,  Sun Joo Lee 4,  Yeo Jin Park 2 5,  Wahyu Widowatib 6,  Rizal Rizal 7 8,  Young Ho Kim 9,  Seo Young Yang 10,  Wei Li 2
Affiliations

Affiliations

  • 1 Health Science Center, School of Biomedical Engineering, Shenzhen University, Shenzhen 518060, China.
  • 2 Korean Medicine (KM) Application Center, Korea Institute of Oriental Medicine, Daegu 41062, Korea.
  • 3 Shenzhen Key Laboratory of Marine Bioresource and Eco-Environmental Science, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen 518060, China.
  • 4 New Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation, 80 Cheombok-ro, Dong-gu, Daegu 41061, Korea.
  • 5 Korean Convergence Medicine, University of Science and Technology, Daejeon 34054, Korea.
  • 6 Medical Research Centre, Faculty of Medicine, Maranatha Christian University, Bandung 40164, Indonesia.
  • 7 Biomolecular Biomedical Research Center for Biology, Indoensian Institute of Sciences, Bandung 40163, Indonesia.
  • 8 Biomedical Engineering, Department of Electrical Engineering, Faculty of Engineering, Universitas Indonesia, West Java 16424, Indonesia.
  • 9 College of Pharmacy, Chungnam National University, Daejeon 34134, Korea.
  • 10 Department of Pharmaceutical Engineering, Sangji University, 83 Sangjidae-gil, Wonju-si 26339, Korea.
PMID: 34579387 DOI: 10.3390/plants10091855
Abstract

Three undescribed bicyclo[3.2.1]octanoid neolignan glucosides, along with a known neolignan, were isolated from the leaves of Piper crocatum Ruiz & Pav. Their chemical structures were elucidated using extensive spectroscopic analyses including 1D and 2D NMR experiments and HR-ESI-MS analysis, as well as through comparison with previously reported data. Two compounds were assessed for their inhibitory effect against pyruvate dehydrogenase E1α S300 phosphorylation. The fluorescent image suggested that both compounds (60 µM) revealed a stronger inhibition effect than the positive control (dichloroacetate, DCA 5 mM), with IC50 values of 99.82 µM and 80.25 µM, respectively.

Keywords

Piper crocatum Ruiz & Pav; Piperaceae; antineoplastic cell agents; neolignan.

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