2. Academic Validation
  3. Picolinafen exerts developmental toxicity via the suppression of oxidative stress and angiogenesis in zebrafish embryos

Picolinafen exerts developmental toxicity via the suppression of oxidative stress and angiogenesis in zebrafish embryos

  • Pestic Biochem Physiol. 2021 Jan:171:104734. doi: 10.1016/j.pestbp.2020.104734.
Jin-Young Lee 1,  Sunwoo Park 2,  Whasun Lim 3,  Gwonhwa Song 4
Affiliations

Affiliations

  • 1 Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
  • 2 Institute of Animal Molecular Biotechnology, Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 02841, Republic of Korea.
  • 3 Department of Food and Nutrition, Kookmin University, Seoul 02707, Republic of Korea. Electronic address: wlim@kookmin.ac.kr.
  • 4 Institute of Animal Molecular Biotechnology, Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 02841, Republic of Korea. Electronic address: ghsong@korea.ac.kr.
PMID: 33357556 DOI: 10.1016/j.pestbp.2020.104734
Abstract

Picolinafen, a phytoene desaturase-inhibiting Herbicide, has been used since 2001 to control the growth of broadleaf weeds. Picolinafen has lower solubility and volatility, and shows lower toxicity to non-target insect species than Other types of Herbicide. Although picolinafen has been detected in lakes near urban environments and induces chronic toxicity in the mammals, birds, and some aquatic organisms, no study has investigated the toxicity or mode of action of picolinafen in zebrafish. In this study, we demonstrated the lethality and acute LC50 value of picolinafen towards zebrafish embryos. Picolinafen hampered the development of embryos by the induction of morphological abnormalities via Apoptosis. Additionally, picolinafen suppressed the generation of Reactive Oxygen Species and angiogenesis. Also, the angiogenesis related genes, flt1 and flt4 mRNA expression was decreased in zebrafish embryos. This study provides a mechanistic understanding of the developmental toxicity of picolinafen in vertebrates.

Keywords

Angiogenesis; Developmental toxicity; Oxidative stress; Picolinafen; Zebrafish.

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