2. Academic Validation
  3. Immunological effects of sublingual immunotherapy with Japanese cedar pollen extract in patients with combined Japanese cedar and Japanese cypress pollinosis

Immunological effects of sublingual immunotherapy with Japanese cedar pollen extract in patients with combined Japanese cedar and Japanese cypress pollinosis

  • Clin Immunol. 2020 Jan:210:108310. doi: 10.1016/j.clim.2019.108310.
Hirotaka Kikuoka 1,  Hideaki Kouzaki 1,  Koji Matsumoto 2,  Hiroyuki Arai 2,  Sayuri Yamamoto 2,  Ichiro Tojima 2,  Shino Shimizu 2,  Hiromi Miyashita 3,  Yukiko Ogawa 3,  Toshihiro Osada 4,  Mitsuhiro Okano 5,  Atsushi Yuta 6,  Takeshi Shimizu 2
Affiliations

Affiliations

  • 1 Department of Otorhinolaryngology, Shiga University of Medical Science, Seta-tsukinowa, Otsu, Shiga 520-2192, Japan. Electronic address: hkohzaki@belle.shiga-med.ac.jp.
  • 2 Department of Otorhinolaryngology, Shiga University of Medical Science, Seta-tsukinowa, Otsu, Shiga 520-2192, Japan.
  • 3 Yuta Clinic, 2-3, Shusei, Tsu, Mie 514-0837, Japan.
  • 4 Discovery and Preclinical Research Division, Taiho Pharmaceutical Co., Ltd, 3, Okubo, Tsukuba, Ibaraki 300-2611, Japan.
  • 5 Department of Otorhinolaryngology, International University of Health and Welfare, 4-3, Kozunomori, Narita, Chiba 286-0048, Japan.
  • 6 Department of Otorhinolaryngology, Shiga University of Medical Science, Seta-tsukinowa, Otsu, Shiga 520-2192, Japan; Yuta Clinic, 2-3, Shusei, Tsu, Mie 514-0837, Japan.
PMID: 31743749 DOI: 10.1016/j.clim.2019.108310
Abstract

Sublingual immunotherapy (SLIT) with Japanese cedar (JCe) pollinosis was expected to be effective for Japanese cypress (JCy) pollinosis. However, only a half of JCy pollinosis patients clinically improved. Therefore, we examined the immunological effect of SLIT for JCy pollinosis. Peripheral blood mononuclear cells (PBMCs) from patients with JCe and JCy pollinosis who did and did not receive SLIT were incubated with Cry j 1, Cha o 1 and Cha o 3 antigens. Basophil activation test (BAT) were performed. Production of IL-5 and IL-17 induced by antigens was inhibited in the SLIT group. Cry j 1-specific production of IL-10 was increased, and serum Cry j 1-specific IgE and -IgG4 were elevated. However, Cha o 1- or Cha o 3-specific production of IL-10 and specific IgG4 was not increased. Antigens-specific BAT did not decrease after SLIT. New SLIT with JCe and JCy is needed for patients with combined JCe and JCy pollinosis.

Keywords

Cha o 3; Cry j 1; Japanese cedar pollinosis; Japanese cypress pollinosis; Sublingual immunotherapy.

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