2. Academic Validation
  3. Fusaproliferin, a Fungal Mycotoxin, Shows Cytotoxicity against Pancreatic Cancer Cell Lines

Fusaproliferin, a Fungal Mycotoxin, Shows Cytotoxicity against Pancreatic Cancer Cell Lines

  • Molecules. 2018 Dec 11;23(12):3288. doi: 10.3390/molecules23123288.
Nazia Hoque 1 2 3,  Choudhury Mahmood Hasan 4,  Md Sohel Rana 5,  Amrit Varsha 6,  Md Hossain Sohrab 7,  Khondaker Miraz Rahman 8
Affiliations

Affiliations

  • 1 Department of Pharmacy, East West University, Dhaka 1212, Bangladesh. nzh@ewubd.edu.
  • 2 Department of Pharmacy, Jahangirnagar University, Savar, Dhaka 1342, Bangladesh. nzh@ewubd.edu.
  • 3 Pharmaceutical Sciences Research Division (PSRD), BCSIR Laboratories, Dhaka 1205, Bangladesh. nzh@ewubd.edu.
  • 4 Department of Pharmaceutical Chemistry, University of Dhaka, Dhaka-1000, Bangladesh. cmhasan@gmail.com.
  • 5 Department of Pharmacy, Jahangirnagar University, Savar, Dhaka 1342, Bangladesh. sohelrana.ju@gmail.com.
  • 6 School of Cancer and Pharmaceutical Science, King's College London, 150 Stamford Street, London SE1 9NH, UK. amritvarsha7dec@gmail.com.
  • 7 Pharmaceutical Sciences Research Division (PSRD), BCSIR Laboratories, Dhaka 1205, Bangladesh. mhsohrab@bcsir.gov.bd.
  • 8 School of Cancer and Pharmaceutical Science, King's College London, 150 Stamford Street, London SE1 9NH, UK. k.miraz.rahman@kcl.ac.uk.
PMID: 30545017 DOI: 10.3390/molecules23123288
Abstract

As a part of our ongoing research on endophytic fungi, we have isolated a sesterterpene mycotoxin, fusaproliferin (FUS), from a Fusarium solani strain, which is associated with the plant Aglaonema hookerianum Schott. FUS showed rapid and sub-micromolar IC50 against pancreatic Cancer cell lines. Time-dependent survival analysis and microscopy imaging showed rapid morphological changes in Cancer cell lines 4 h after incubation with FUS. This provides a new chemical scaffold that can be further developed to obtain more potent synthetic agents against pancreatic Cancer.

Keywords

cytotoxic activity; endophytic fungi; pancreatic cancer; sesterterpene.

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