2. Academic Validation
  3. The enantioselective total synthesis of nemotin

The enantioselective total synthesis of nemotin

  • Org Biomol Chem. 2010 Feb 21;8(4):811-21. doi: 10.1039/b923123d.
Ya-Jun Jian 1,  Yikang Wu
Affiliations

Affiliation

  • 1 State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai, 200032, China.
PMID: 20135038 DOI: 10.1039/b923123d
Abstract

The allene-diyne natural product nemotin was synthesized for the first time through an enantioselective route with the stereogenic center at the lactone moiety derived from l-glutamic acid and the allene axis constructed from the corresponding propargylic tosylate, and the absolute configuration was thus established as (4S,5aS).

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