2. Academic Validation
  3. Carnitine conjugate of nipecotic acid: a new example of dual prodrug

Carnitine conjugate of nipecotic acid: a new example of dual prodrug

  • Molecules. 2009 Aug 31;14(9):3268-74. doi: 10.3390/molecules14093268.
Carmela Napolitano 1,  Martina Scaglianti,  Emanuela Scalambra,  Stefano Manfredini,  Luca Ferraro,  Sarah Beggiato,  Silvia Vertuani
Affiliations

Affiliation

  • 1 Department of Pharmaceutical Sciences, University of Ferrara, Via Fossato di Mortara 17-19, I-44100 Ferrara, Italy.
PMID: 19783924 DOI: 10.3390/molecules14093268
Abstract

As a novel example of improved entry of poorly delivered drugs into the brain by means of nutrient conjugates, L-carnitine was conjugated to nipecotic acid and the capacity to antagonize PTZ-induced convulsions of this novel entity was evaluated.

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