2. Academic Validation
  3. Hexylitaconic acid: a new inhibitor of p53-HDM2 interaction isolated from a marine-derived fungus, Arthrinium sp

Hexylitaconic acid: a new inhibitor of p53-HDM2 interaction isolated from a marine-derived fungus, Arthrinium sp

  • Bioorg Med Chem Lett. 2006 Jan 1;16(1):69-71. doi: 10.1016/j.bmcl.2005.09.052.
Sachiko Tsukamoto 1,  Takushi Yoshida,  Hidetaka Hosono,  Tomihisa Ohta,  Hideyoshi Yokosawa
Affiliations

Affiliation

  • 1 Graduate School of Natural Science and Technology, Kanazawa University, Kanazawa 920-1192, Japan. sachiko@p.kanazawa-u.ac.jp
PMID: 16246554 DOI: 10.1016/j.bmcl.2005.09.052
Abstract

A new inhibitor of p53-HDM2 interaction was isolated from a culture of marine-derived fungus, Arthrinium sp. The structure was identified to be (-)-hexylitaconic acid (1) by spectroscopic analysis. The inhibition of p53-HDM2 binding was tested by the ELISA method, and 1 inhibited the binding with an IC(50) value of 50 microg/mL. Although a number of synthetic inhibitors of p53-HDM2 interaction have been reported so far, 1 is the second inhibitor isolated from natural resources.

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