2. Academic Validation
  3. Glisoprenins, new inhibitors of acyl-CoA: cholesterol acyltransferase produced by Gliocladium sp. FO-1513. II. Structure elucidation of glisoprenins A and B

Glisoprenins, new inhibitors of acyl-CoA: cholesterol acyltransferase produced by Gliocladium sp. FO-1513. II. Structure elucidation of glisoprenins A and B

  • J Antibiot (Tokyo). 1992 Oct;45(10):1669-76. doi: 10.7164/antibiotics.45.1669.
H Nishida 1,  X H Huang,  H Tomoda,  S Omura
Affiliations

Affiliation

  • 1 Research Center for Biological Function, Kitasato Institute, Tokyo, Japan.
PMID: 1473995 DOI: 10.7164/antibiotics.45.1669
Abstract

The structure of glisoprenins A and B, novel acyl-CoA: cholesterol Acyltransferase (ACAT) inhibitors, was determined by spectroscopic analyses, mainly 1H and 13C NMR and MS. Glisoprenin A was deduced to be a tetrahydroxynonaprenol and glisoprenin B to be an oxidative modification of glisoprenin A.

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