2. Academic Validation
  3. Isolation, and biological properties of a new cell cycle inhibitor, curvularol, isolated from Curvularia sp. RK97-F166

Isolation, and biological properties of a new cell cycle inhibitor, curvularol, isolated from Curvularia sp. RK97-F166

  • J Antibiot (Tokyo). 2001 Jan;54(1):10-6. doi: 10.7164/antibiotics.54.10.
Y Honda 1,  M Ueki,  G Okada,  R Onose,  R Usami,  K Horikoshi,  H Osada
Affiliations

Affiliation

  • 1 RIKEN Institute, Saitama, Japan.
PMID: 11269706 DOI: 10.7164/antibiotics.54.10
Abstract

A new cell growth inhibitor, curvularol, was isolated from the fermentation broth of Curvularia sp. RK97-F166. Curvularol showed no Antibacterial activity, and very weak Antifungal activity. However, curvularol inhibited the cell cycle progression of normal rat kidney (NRK) cells in G1 phase at 150 ng/ml. Curvularol induced the morphological reversion of srcts-transformed NRK cells at 100 ng/ml, and inhibited protein synthesis same as cycloheximide.

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