2. Academic Validation
  3. Synthesis of benzylideneacetophenones and their inhibition of lipid peroxidation

Synthesis of benzylideneacetophenones and their inhibition of lipid peroxidation

  • Eur J Med Chem. 2000 Apr;35(4):449-57. doi: 10.1016/s0223-5234(00)00137-9.
I S Arty 1,  H Timmerman,  M Samhoedi,  Sastrohamidjojo,  Sugiyanto,  H van der Goot
Affiliations

Affiliation

  • 1 FPMIPA IKIP Yogyakarta, Karangmalang, Yogyakarta, Indonesia.
PMID: 10858605 DOI: 10.1016/s0223-5234(00)00137-9
Abstract

A series of benzylideneacetophenone derivatives have been synthesized and found to show potent inhibition of the lipid peroxidation (LPO) in rat liver microsomes. All 19 compounds prepared in this series are LPO inhibitors. The highest activity was found in para hydroxy derivatives with two meta tert-butyl substituents.

Figures
Products