Usp53 - ubiquitin specific peptidase 53 Gene

Mus musculus

Also known as Sp6; mbo; Phxr3; mKIAA1350

Gene ID: 99526 | Gene type: protein coding

About Usp53

Summary

Predicted to enable thiol-dependent Deubiquitinase. Acts upstream of or within several processes, including neuron apoptotic process; response to auditory stimulus; and sensory perception of sound. Located in cell-cell junction. Is expressed in olfactory epithelium; submandibular gland primordium; and tooth. Orthologous to human USP53 (ubiquitin specific peptidase 53). [provided by Alliance of Genome Resources, Apr 2022]

Usp53 Products(8)

mRNA	Protein	Name
NM_001411523.1	NP_001398452.1	inactive ubiquitin carboxyl-terminal hydrolase 53 isoform 1
NM_001411527.1	NP_001398456.1	inactive ubiquitin carboxyl-terminal hydrolase 53 isoform 2
NM_001411528.1	NP_001398457.1	inactive ubiquitin carboxyl-terminal hydrolase 53 isoform 2
NM_001411529.1	NP_001398458.1	inactive ubiquitin carboxyl-terminal hydrolase 53 isoform 2
NM_001411530.1	NP_001398459.1	inactive ubiquitin carboxyl-terminal hydrolase 53 isoform 3
NM_001411531.1	NP_001398460.1	inactive ubiquitin carboxyl-terminal hydrolase 53 isoform 4
NM_001411532.1	NP_001398461.1	inactive ubiquitin carboxyl-terminal hydrolase 53 isoform 5
NM_133857.4	NP_598618.1	inactive ubiquitin carboxyl-terminal hydrolase 53 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
NOT enables deubiquitinase activity	IDA IDA: Inferred from direct assay	26609154	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	26609154	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within action potential	IMP IMP: Inferred from mutant phenotype	26609154	MGI
acts upstream of or within epithelial cell apoptotic process	IMP IMP: Inferred from mutant phenotype	26609154	MGI
acts upstream of or within neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	26609154	MGI
acts upstream of or within outer hair cell apoptotic process	IMP IMP: Inferred from mutant phenotype	26609154	MGI
NOT acts upstream of or within protein deubiquitination	IDA IDA: Inferred from direct assay	26609154	MGI
acts upstream of or within response to auditory stimulus	IMP IMP: Inferred from mutant phenotype	26609154	MGI
acts upstream of or within sensory perception of sound	IMP IMP: Inferred from mutant phenotype	17329413	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell-cell junction	IDA IDA: Inferred from direct assay	26609154	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

inactive ubiquitin carboxyl-terminal hydrolase 53

inactive ubiquitin-specific peptidase 53	per-hexamer repeat gene 3
per-hexamer repeat protein 3	protein mambo
ubiquitin specific protease 53

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15564	USP53 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20514	Usp53 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27023	Usp53 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Usp53	NCBI	NCBI:54532

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