Atp1a2 - ATPase, Na+/K+ transporting, alpha 2 polypeptide Gene

Mus musculus

Also known as Atpa-3; mKIAA0778

Gene ID: 98660 | Gene type: protein coding

About Atp1a2

Summary

Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and alkali metal ion binding activity. Involved in several processes, including cellular response to steroid hormone stimulus; locomotory exploration behavior; and response to auditory stimulus. Acts upstream of or within several processes, including forebrain development; regulation of blood circulation; and regulation of muscle contraction. Located in T-tubule; cell projection; and neuronal cell body. Is expressed in several structures, including genitourinary system; heart; musculature; nervous system; and sensory organ. Used to study familial hemiplegic migraine 2. Human ortholog(s) of this gene implicated in alternating hemiplegia of childhood; benign neonatal seizures; familial hemiplegic migraine 2; hypertension; and migraine with aura. Orthologous to human ATP1A2 (ATPase Na+/K+ transporting subunit alpha 2). [provided by Alliance of Genome Resources, Apr 2022]

Atp1a2 Products(1)

mRNA	Protein	Name
NM_178405.3	NP_848492.1	sodium/potassium-transporting ATPase subunit alpha-2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15485817	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within L-ascorbic acid metabolic process	IGI IGI: Inferred from genetic interaction	33544780	MGI
acts upstream of or within adult locomotory behavior	IMP IMP: Inferred from mutant phenotype	17234593	MGI
acts upstream of or within amygdala development	IMP IMP: Inferred from mutant phenotype	12805306	MGI
acts upstream of or within behavioral fear response	IMP IMP: Inferred from mutant phenotype	12805306	MGI
acts upstream of or within blood circulation	IGI IGI: Inferred from genetic interaction	33544780	MGI
involved in cellular response to steroid hormone stimulus	IDA IDA: Inferred from direct assay	16243970	MGI
acts upstream of or within fear response	IMP IMP: Inferred from mutant phenotype	21731499	MGI
acts upstream of or within locomotion	IMP IMP: Inferred from mutant phenotype	12458206	MGI
involved in locomotory exploration behavior	IMP IMP: Inferred from mutant phenotype	20936682	MGI
acts upstream of or within membrane depolarization	IMP IMP: Inferred from mutant phenotype	30819023	MGI
acts upstream of or within negative regulation of cytosolic calcium ion concentration	IMP IMP: Inferred from mutant phenotype	10360172	MGI
acts upstream of or within negative regulation of heart contraction	IMP IMP: Inferred from mutant phenotype	10360172	MGI
acts upstream of or within negative regulation of striated muscle contraction	IMP IMP: Inferred from mutant phenotype	11507009	MGI
acts upstream of or within neuronal action potential propagation	IMP IMP: Inferred from mutant phenotype	21731499	MGI
acts upstream of or within neurotransmitter uptake	IMP IMP: Inferred from mutant phenotype	12805306	MGI
involved in neurotransmitter uptake	IMP IMP: Inferred from mutant phenotype	12805306	MGI
acts upstream of or within olfactory cortex development	IMP IMP: Inferred from mutant phenotype	12805306	MGI
acts upstream of or within regulation of blood pressure	IGI IGI: Inferred from genetic interaction	16243970	MGI
acts upstream of or within regulation of muscle contraction	IMP IMP: Inferred from mutant phenotype	10360172	MGI
acts upstream of or within regulation of respiratory gaseous exchange by nervous system process	IMP IMP: Inferred from mutant phenotype	12458206	MGI
acts upstream of or within regulation of smooth muscle contraction	IMP IMP: Inferred from mutant phenotype	14627611	MGI
acts upstream of or within regulation of striated muscle contraction	IMP IMP: Inferred from mutant phenotype	15253893	MGI
acts upstream of or within regulation of the force of heart contraction	IMP IMP: Inferred from mutant phenotype	10360172	MGI
acts upstream of or within regulation of vasoconstriction	IGI IGI: Inferred from genetic interaction	14627611	MGI
acts upstream of or within regulation of vasoconstriction	IMP IMP: Inferred from mutant phenotype	14627611	MGI
involved in response to auditory stimulus	IMP IMP: Inferred from mutant phenotype	20936682	MGI
involved in response to glycoside	IMP IMP: Inferred from mutant phenotype	16243970	MGI
acts upstream of or within response to potassium ion	IMP IMP: Inferred from mutant phenotype	30819023	MGI
acts upstream of or within visual learning	IMP IMP: Inferred from mutant phenotype	17234593	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in T-tubule	IDA IDA: Inferred from direct assay	16292983	MGI
located in cell projection	IDA IDA: Inferred from direct assay	12458206	MGI
is active in cell surface	IDA IDA: Inferred from direct assay	17804407	MGI
is active in endoplasmic reticulum	IDA IDA: Inferred from direct assay	21731499	MGI
located in neuronal cell body	IDA IDA: Inferred from direct assay	12458206	MGI
is active in plasma membrane	IDA IDA: Inferred from direct assay	21731499	MGI
part of protein-containing complex	IDA IDA: Inferred from direct assay	17804407	MGI
located in sarcolemma	IDA IDA: Inferred from direct assay	15485817	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

sodium/potassium-transporting ATPase subunit alpha-2

Na(+)/K(+) ATPase alpha(+) subunit	Na(+)/K(+) ATPase alpha-2 subunit
sodium pump subunit alpha-2

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01183	ATP1A2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS01187	ATP1B2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21822	Atp1a2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21823	Atp1b2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28339	Atp1a2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Atp1a2	NCBI	NCBI:477

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