LCMT2 - leucine carboxyl methyltransferase 2 Gene

Homo sapiens

Also known as PPM2; TYW4

Gene ID: 9836 | Gene type: protein coding

About LCMT2

Cytogenetic location: 15q15.3 Genomic coordinates (GRCh38): 15:43,323,649-43,330,573 (from NCBI)

This gene has 2 transcripts (splice variants), 152 orthologues and 1 paralogue.

Summary

The protein encoded by this intronless gene belongs to the highly variable methyltransferase superfamily. This gene is the inferred homolog of the Saccharomyces cerevisiae carboxymethyltransferase gene PPM2 that is essential for the synthesis of the hypermodified guanosine Wybutosine (yW). [provided by RefSeq, Jul 2008]

LCMT2 Products(1)

mRNA	Protein	Name
NM_014793.5	NP_055608.2	tRNA wybutosine-synthesizing protein 4

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25910212	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LCMT2 Protein Structure

LCM

Kelch_6

0
200
400
600
686 a.a.

Protein Preferred Names

Protein Names

tRNA wybutosine-synthesizing protein 4

p21WAF1/CIP1 promoter-interacting protein

Related Diseases

Diseases

Alias

Cerebral Creatine Deficiency Syndrome 3

Arginine:Glycine Amidinotransferase Deficiency	Agat Deficiency
Gatm Deficiency	Creatine Deficiency Syndrome Due To Agat Deficiency
L-Arginine:Glycine Amidinotransferase Deficiency	CCDS3
L-Arginine:Glycine Aminidotransferase Deficiency	Deficiency, Cerebral Creatine, Syndrome, Type 3

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07553	LCMT2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	LCMT2	VGNC	VGNC:42610
Macaca mulatta	LCMT2	VGNC	VGNC:108312
Rattus norvegicus	LCMT2	RGD	RGD:1305829
Mus musculus	LCMT2	MGD	MGI:1353659
Bos taurus	LCMT2	VGNC	VGNC:30813

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