USP6NL - USP6 N-terminal like Gene

Homo sapiens

Also known as RNTRE; TRE2NL; USP6NL-IT1

Gene ID: 9712 | Gene type: protein coding

About USP6NL

Cytogenetic location: 10p14 Genomic coordinates (GRCh38): 10:11,460,510-11,611,650 (from NCBI)

This gene has 6 transcripts (splice variants), 217 orthologues and 45 paralogues. Broad expression in testis (RPKM 11.0), esophagus (RPKM 10.8) and 24 other tissues.

Summary

Enables GTPase activator activity and small GTPase binding activity. Involved in several processes, including plasma membrane to endosome transport; positive regulation of GTPase activity; and retrograde transport, plasma membrane to Golgi. Located in cytoplasmic vesicle and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

USP6NL Products(5)

mRNA	Protein	Name
NM_001080491.5	NP_001073960.1	USP6 N-terminal-like protein isoform 2
NM_001391959.1	NP_001378888.1	USP6 N-terminal-like protein isoform 3
NM_001391960.1	NP_001378889.1	USP6 N-terminal-like protein isoform 4
NM_001391961.1	NP_001378890.1	USP6 N-terminal-like protein isoform 5
NM_014688.5	NP_055503.1	USP6 N-terminal-like protein isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables GTPase activator activity	IDA IDA: Inferred from direct assay	17562788	GOA
enables small GTPase binding	IPI IPI: Inferred from physical interaction	17562788	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in Golgi organization	IMP IMP: Inferred from mutant phenotype	17684057	GOA
involved in plasma membrane to endosome transport	IMP IMP: Inferred from mutant phenotype	17562788	GOA
involved in positive regulation of GTPase activity	IDA IDA: Inferred from direct assay	17562788	GOA
involved in regulation of Golgi organization	IMP IMP: Inferred from mutant phenotype	17562788	GOA
NOT involved in regulation of cilium assembly	IMP IMP: Inferred from mutant phenotype	17646400	GOA
involved in retrograde transport, plasma membrane to Golgi	IMP IMP: Inferred from mutant phenotype	17684057	GOA
involved in virion assembly	IMP IMP: Inferred from mutant phenotype	21680502	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasmic vesicle	IDA IDA: Inferred from direct assay	17684057	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	17562788	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

USP6NL Protein Structure

RabGAP-TBC

0
200
400
600
828 a.a.

Protein Preferred Names

Protein Names

USP6 N-terminal-like protein

related to the N-terminus of tre

Related Diseases

Diseases

Alias

Nipah Virus Encephalitis

Equine Morbillivirus

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15567	USP6NL Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS20616	Usp6nl Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS27124	Usp6nl Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	USP6NL	VGNC	VGNC:48204
Macaca mulatta	USP6NL	VGNC	VGNC:79055
Rattus norvegicus	USP6NL	RGD	RGD:1311786
Bos taurus	USP6NL	VGNC	VGNC:36737
Mus musculus	USP6NL	MGD	MGI:2138893
Felis catus	USP6NL	VGNC	VGNC:66897

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