MMGT1 - membrane magnesium transporter 1 Gene

Homo sapiens

Also known as EMC5; TMEM32

Gene ID: 93380 | Gene type: protein coding

About MMGT1

This gene has 4 transcripts (splice variants), 223 orthologues, 1 paralogue and is associated with 1 phenotype. Ubiquitous expression in thyroid (RPKM 15.3), bone marrow (RPKM 10.9) and 25 other tissues.

Summary

Contributes to membrane insertase activity. Involved in protein insertion into ER membrane by stop-transfer membrane-anchor sequence and tail-anchored membrane protein insertion into ER membrane. Is integral component of endoplasmic reticulum membrane. Part of EMC complex. [provided by Alliance of Genome Resources, Apr 2022]

MMGT1 Products(2)

mRNA	Protein	Name
NM_001330000.2	NP_001316929.1	ER membrane protein complex subunit 5 precursor
NM_173470.3	NP_775741.1	ER membrane protein complex subunit 5 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
contributes to membrane insertase activity	IMP IMP: Inferred from mutant phenotype	29809151	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	22119785	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in protein insertion into ER membrane by stop-transfer membrane-anchor sequence	IDA IDA: Inferred from direct assay	29242231	GOA
involved in protein insertion into ER membrane by stop-transfer membrane-anchor sequence	IMP IMP: Inferred from mutant phenotype	29809151	GOA
involved in tail-anchored membrane protein insertion into ER membrane	IDA IDA: Inferred from direct assay	29242231	GOA
involved in tail-anchored membrane protein insertion into ER membrane	IMP IMP: Inferred from mutant phenotype	29242231	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of EMC complex	IDA IDA: Inferred from direct assay	22119785	GOA
part of EMC complex	IPI IPI: Inferred from physical interaction	32439656	GOA
located in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	32439656	GOA
located in membrane	IDA IDA: Inferred from direct assay	22119785	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MMGT1 Protein Structure

MMgT

0
100
131 a.a.

Protein Preferred Names

Protein Names

ER membrane protein complex subunit 5

transmembrane protein 32

MMGT1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MMGT1	Q8N4V1	SLC35B4	Homo sapiens	Q969S0	Validated Y2H	32296183
Intra	MMGT1	Q8N4V1	DEFB127	Homo sapiens	Q9H1M4	Validated Y2H	32296183
Intra	MMGT1	Q8N4V1	SLC38A7	Homo sapiens	Q9NVC3	Validated Y2H	32296183
Intra	MMGT1	Q8N4V1	NINJ2	Homo sapiens	Q9NZG7	Validated Y2H	32296183
Intra	MMGT1	Q8N4V1	ADGRE2	Homo sapiens	Q9UHX3	Validated Y2H	32296183
Intra	MMGT1	Q8N4V1	PLPP6	Homo sapiens	Q8IY26	Y2H Array	32296183
Intra	MMGT1	Q8N4V1	MFF	Homo sapiens	Q9GZY8-5	Validated Y2H	32296183
Intra	MMGT1	Q8N4V1	TMEM254	Homo sapiens	Q8TBM7	Validated Y2H	32296183
Intra	MMGT1	Q8N4V1	TMEM254	Homo sapiens	Q8TBM7	Y2H Array	32296183
Intra	MMGT1	Q8N4V1	C4orf3	Homo sapiens	Q8WVX3-2	Validated Y2H	32296183
Intra	MMGT1	Q8N4V1	LNPEP	Homo sapiens	Q9UIQ6-2	Validated Y2H	32296183
Intra	MMGT1	Q8N4V1	TMEM229B	Homo sapiens	Q8NBD8	Validated Y2H	32296183
Intra	MMGT1	Q8N4V1	NDUFA3	Homo sapiens	O95167	Anti Tag CoIP	35271311
Intra	MMGT1	Q8N4V1	TMEM14C	Homo sapiens	Q9P0S9	Validated Y2H	32296183
Intra	MMGT1	Q8N4V1	TMEM86B	Homo sapiens	Q8N661	Validated Y2H	32296183
Intra	MMGT1	Q8N4V1	TMEM14A	Homo sapiens	Q9Y6G1	Validated Y2H	32296183
Intra	MMGT1	Q8N4V1	EMC6	Homo sapiens	Q9BV81	Validated Y2H	32296183
Intra	MMGT1	Q8N4V1	EMC6	Homo sapiens	Q9BV81	Pull Down	22119785
Intra	MMGT1	Q8N4V1	TMEM60	Homo sapiens	Q9H2L4	Validated Y2H	32296183
Intra	MMGT1	Q8N4V1	TECR	Homo sapiens	Q9NZ01	Validated Y2H	32296183
Intra	MMGT1	Q8N4V1	FIS1	Homo sapiens	Q9Y3D6	Validated Y2H	32296183
Intra	MMGT1	Q8N4V1	EMC2	Homo sapiens	Q15006	Pull Down	22119785
Intra	MMGT1	Q8N4V1	EMC2	Homo sapiens	Q15006	Anti Tag CoIP	35271311
Intra	MMGT1	Q8N4V1	EMC2	Homo sapiens	Q15006	Anti Tag CoIP	26496610
Intra	MMGT1	Q8N4V1	EMC2	Homo sapiens	Q15006	Anti Tag CoIP	32439656
Intra	MMGT1	Q8N4V1	EMC2	Homo sapiens	Q15006	Anti Tag CoIP	33961781
Intra	MMGT1	Q8N4V1	AGR3	Homo sapiens	Q8TD06	Validated Y2H	32296183
Intra	MMGT1	Q8N4V1	SLC7A14	Homo sapiens	Q8TBB6	Validated Y2H	32296183
Intra	MMGT1	Q8N4V1	FXYD6	Homo sapiens	Q9H0Q3	Validated Y2H	32296183
Intra	MMGT1	Q8N4V1	STX8	Homo sapiens	Q9UNK0	Validated Y2H	32296183
Intra	MMGT1	Q8N4V1	MFSD3	Homo sapiens	Q96ES6	Validated Y2H	32296183
Intra	MMGT1	Q8N4V1	INSIG2	Homo sapiens	Q9Y5U4	Validated Y2H	32296183
Intra	MMGT1	Q8N4V1	RUSF1	Homo sapiens	Q96GQ5	Validated Y2H	32296183
Intra	MMGT1	Q8N4V1	PEX16	Homo sapiens	Q9Y5Y5	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant MMGT1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77087	MMGT1 Protein, Human (HEK293, His)	Q8N4V1-1/NP_775741.1 (E66-R131)	≥95%

Related Diseases

Diseases

Alias

Chromosome 15q11.2 Deletion Syndrome

15q11.2 Microdeletion Syndrome	15q11.2 Bp1-Bp2 Microdeletion Syndrome
Del(15)(Q11.2)	Monosomy 15q11.2
15q11.2 Microdeletion	Chromosome 15q11.2 Deletion
Chromosome 15q11.2 Microdeletion	Chromosome Deletion Syndrome 15q11.2
Microdeletion 15q11.2	Duplication 15q11-Q13 Syndrome

Fundus Dystrophy

Retinal Dystrophy	Retinal Dystrophies
Dystrophy, Retinal

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08515	MMGT1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	MMGT1	MGD	MGI:2384305
Felis catus	MMGT1	VGNC	VGNC:63536
Bos taurus	MMGT1	VGNC	VGNC:31516
Rattus norvegicus	MMGT1	RGD	RGD:1566339
Others	MMGT1	NCBI

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