BPY2 - basic charge Y-linked 2 Gene

Homo sapiens

Also known as VCY2; BPY2A; VCY2A

Gene ID: 9083 | Gene type: protein coding

About BPY2

Cytogenetic location: Yq11.223 Genomic coordinates (GRCh38): Y:22,984,263-23,005,465 (from NCBI)

This gene has 4 transcripts (splice variants), 4 orthologues, 2 paralogues and is associated with 1 phenotype.

Summary

This gene is located in the nonrecombining portion of the Y chromosome, and expressed specifically in testis. The encoded protein interacts with ubiquitin protein Ligase E3A and may be involved in male germ cell development and male infertility. Three nearly identical copies of this gene exist on chromosome Y; two copies are part of a palindromic region. This record represents the copy outside of the palidromic region. [provided by RefSeq, Jul 2008]

BPY2 Products(1)

mRNA	Protein	Name
NM_004678.3	NP_004669.2	testis-specific basic protein Y 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables HECT domain binding	IPI IPI: Inferred from physical interaction	12207887	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	14627543	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in spermatogenesis	IMP IMP: Inferred from mutant phenotype	12724276	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	12724276	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

testis-specific basic protein Y 2

basic protein on Y chromosome 2

Related Diseases

Diseases

Alias

Spermatogenic Failure, Y-Linked, 2

SPGFY2	Spermatogenic Failure, Nonobstructive, Y-Linked
Y-Linked Spermatogenic Failure 2	Azoospermia, Nonobstructive, Y-Linked
Oligozoospermia, Nonobstructive, Y-Linked	Oligospermia, Nonobstructive, Y-Linked
Spermatogenic Arrest, Y-Linked	Nonobstructive Y-Linked Spermatogenic Failure
Spermatogenic Failure Y-Linked 2	Azoospermia Non-Obstructive Y-Linked
Non-Obstructive Azoospermia And Infertility	Oligospermia Non-Obstructive Y-Linked
Oligozoospermia Non-Obstructive Y-Linked	Spermatogenic Arrest Y-Linked
Spermatogenic Failure Nonobstructive Y-Linked

Male Infertility

Infertility, Male	Infertility Male
Male Sterility	Absolute Infertility

Infertility

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-W004547	(NH2)2bpy		99.91%	Unkown
HY-W127716	Ru(bpy)2(mcbpy-O-Su-ester)(PF6)2		≥97.0%	Unkown
HY-D0148	Ru(bpy)2(phen-ITC)(PF6)2		/	Unkown
HY-RS01587	BPY2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS08031	MAP1S Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-147172	Ru(bpy)2(dcbpy)NHS dihexafluorophosphate		/	Unkown

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