ANGEL2 - angel homolog 2 Gene

Homo sapiens

Also known as Ccr4d; KIAA0759L

Gene ID: 90806 | Gene type: protein coding

About ANGEL2

Cytogenetic location: 1q32.3 Genomic coordinates (GRCh38): 1:212,992,182-213,015,867 (from NCBI)

This gene has 8 transcripts (splice variants), 208 orthologues and 5 paralogues. Ubiquitous expression in brain (RPKM 5.6), lymph node (RPKM 5.1) and 25 other tissues.

Summary

Enables mRNA 3'-UTR binding activity. Involved in 3'-UTR-mediated mRNA stabilization and negative regulation of mitotic cell cycle. Located in Cajal body and cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

ANGEL2 Products(5)

mRNA	Protein	Name
NM_001300753.2	NP_001287682.1	protein angel homolog 2 isoform b
NM_001300755.2	NP_001287684.1	protein angel homolog 2 isoform b
NM_001300757.2	NP_001287686.1	protein angel homolog 2 isoform c
NM_001300758.2	NP_001287687.1	protein angel homolog 2 isoform c
NM_144567.5	NP_653168.2	protein angel homolog 2 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables mRNA 3'-UTR binding	IDA IDA: Inferred from direct assay	22547059	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in 3'-UTR-mediated mRNA stabilization	IMP IMP: Inferred from mutant phenotype	22547059	GOA
involved in negative regulation of mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	22547059	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in Cajal body	IDA IDA: Inferred from direct assay	17178830	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	17178830	GOA
is active in mitochondrial matrix	IDA IDA: Inferred from direct assay	36180430	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ANGEL2 Protein Structure

Exo_endo_phos

0
100
200
300
400
500
544 a.a.

Protein Preferred Names

Protein Names

protein angel homolog 2

Related Diseases

Diseases

Alias

Pontocerebellar Hypoplasia, Type 7

Pontocerebellar Hypoplasia Type 7	PCH7
Pontocerebellar Hypoplasia-46,Xy Disorder Of Sex Development Syndrome	Pontocerebellar Hypoplasia 7
Hypoplasia, Pontocerebellar, Type 7

Rheumatoid Arthritis Interstitial Lung Disease

Rheumatoid Lung

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00686	ANGEL2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	ANGEL2	VGNC	VGNC:37853
Macaca mulatta	ANGEL2	VGNC	VGNC:69737
Felis catus	ANGEL2	VGNC	VGNC:59779
Mus musculus	ANGEL2	MGD	MGI:1196310
Bos taurus	ANGEL2	VGNC	VGNC:25887
Rattus norvegicus	ANGEL2	RGD	RGD:1305056

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