Shc1 - SHC adaptor protein 1 Gene

Rattus norvegicus

Also known as P66shc

Gene ID: 85385 | Gene type: protein coding

About Shc1

Summary

Enables enzyme binding activity; epidermal growth factor receptor binding activity; and phosphotyrosine residue binding activity. Involved in several processes, including positive regulation of smooth muscle cell proliferation; positive regulation of vasoconstriction; and response to peptide hormone. Located in endosome membrane; nucleus; and plasma membrane. Part of Shc-EGFR complex. Used to study glomerulosclerosis. Biomarker of familial hyperlipidemia and hepatocellular carcinoma. Orthologous to human SHC1 (SHC adaptor protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Shc1 Products(2)

mRNA	Protein	Name
NM_001164060.2	NP_001157532.1	SHC-transforming protein 1 isoform a
NM_053517.3	NP_445969.2	SHC-transforming protein 1 isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables epidermal growth factor receptor binding	IPI IPI: Inferred from physical interaction	7513704	RGD
enables phosphoprotein binding	IPI IPI: Inferred from physical interaction	8910399	RGD
enables phosphotyrosine residue binding	IPI IPI: Inferred from physical interaction	9271418	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	11694516	RGD
enables protein phosphatase 2A binding	IDA IDA: Inferred from direct assay	11884620	RGD
enables protein phosphatase 2A binding	IPI IPI: Inferred from physical interaction	11884620	RGD
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	11884620	RGD
enables receptor tyrosine kinase binding	IPI IPI: Inferred from physical interaction	9582017	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in actin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	15262993	RGD
involved in animal organ regeneration	IEP IEP: Inferred from expression pattern	15067377	RGD
involved in cellular response to insulin stimulus	IEP IEP: Inferred from expression pattern	11884620	RGD
involved in insulin receptor signaling pathway	IDA IDA: Inferred from direct assay	17925406	RGD
involved in insulin receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	7513704	RGD
involved in neuron differentiation	IMP IMP: Inferred from mutant phenotype	17274988	RGD
involved in neuron projection development	IMP IMP: Inferred from mutant phenotype	15485499	RGD
involved in positive regulation of MAPK cascade	IMP IMP: Inferred from mutant phenotype	15262993	RGD
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	7513704	RGD
involved in positive regulation of smooth muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	12837289	RGD
involved in positive regulation of vasoconstriction	IMP IMP: Inferred from mutant phenotype	16242150	RGD
involved in regulation of smooth muscle contraction	IMP IMP: Inferred from mutant phenotype	27270176	RGD
involved in response to endothelin	IMP IMP: Inferred from mutant phenotype	27270176	RGD
involved in response to glucocorticoid	IEP IEP: Inferred from expression pattern	10612430	RGD
involved in response to hydrogen peroxide	IEP IEP: Inferred from expression pattern	16699171	RGD
involved in response to hypoxia	IEP IEP: Inferred from expression pattern	16439820	RGD
involved in response to insulin	IEP IEP: Inferred from expression pattern	11954667	RGD
involved in response to nicotine	IEP IEP: Inferred from expression pattern	17068140	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	16699171	RGD
involved in response to toxic substance	IEP IEP: Inferred from expression pattern	16699171	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
part of Shc-EGFR complex	IDA IDA: Inferred from direct assay	7513704	RGD
located in endosome membrane	IDA IDA: Inferred from direct assay	17363458	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

SHC-transforming protein 1

SH2 domain protein C1	SHC (Src homology 2 domain containing) transforming protein 1
src homology 2 domain-containing-transforming protein C1

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12856	SHC1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS21432	Shc1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS27950	Shc1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Shc1	NCBI	NCBI:6464

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