2. Gene
  3. Glis2 - GLIS family zinc finger 2 Gene

Glis2 - GLIS family zinc finger 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Nkl; Gli5; Klf16

Gene ID: 83396 | Gene type: protein coding

About Glis2

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in negative regulation of smoothened signaling pathway and regulation of transcription, DNA-templated. Acts upstream of or within several processes, including hematopoietic stem cell homeostasis; positive regulation of protein localization to nucleus; and regulation of transcription by RNA polymerase II. Located in cytoplasm; non-motile cilium; and nuclear speck. Is expressed in several structures, including early conceptus; gut; nervous system; oocyte; and retina layer. Used to study nephronophthisis 7. Human ortholog(s) of this gene implicated in nephronophthisis 7. Orthologous to human GLIS2 (GLIS family zinc finger 2). [provided by Alliance of Genome Resources, Apr 2022]

Glis2 Products(1)

mRNA Protein Name
NM_031184.3 NP_112461.2 zinc finger protein GLIS2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables DNA binding IDA
IDA: Inferred from direct assay
11262234 MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
21127075 MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
18298960 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
17344476 MGI
enables transcription cis-regulatory region binding IDA
IDA: Inferred from direct assay
21127075 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within cell differentiation involved in kidney development IMP
IMP: Inferred from mutant phenotype
17618285 MGI
acts upstream of or within hematopoietic stem cell homeostasis IMP
IMP: Inferred from mutant phenotype
26880577 MGI
acts upstream of or within kidney development IMP
IMP: Inferred from mutant phenotype
18227149 MGI
involved in negative regulation of DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
21127075 MGI
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
11741991 MGI
involved in negative regulation of smoothened signaling pathway IMP
IMP: Inferred from mutant phenotype
21816948 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
17618285 MGI
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
21127075 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
17618285 MGI
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
11741991 MGI
acts upstream of or within positive regulation of protein localization to nucleus IGI
IGI: Inferred from genetic interaction
17344476 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
21127075 MGI
acts upstream of or within regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
18227149 MGI
Cellular Component GO Annotation Evidence Reference Source
located in non-motile cilium IDA
IDA: Inferred from direct assay
17618285 MGI
located in nuclear speck IDA
IDA: Inferred from direct assay
11741991 MGI
located in nucleus IDA
IDA: Inferred from direct assay
18227149 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

zinc finger protein GLIS2

GLI-Kruppel family member GLI5

GLI-similar 2

Kruppel-like factor 16 (neuronal)

neuronal Krueppel-like protein

zinc finger protein GLI5

Related Agents

Pre-clinical Phase
Bioactive Molecules (9)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-13901 GANT 61 99.66% Unkown
HY-RS05475 GLI2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-12487 NL-103 Inhibitor / Unkown
HY-137567 Prostaglandin E1 ethanolamide Activator / Unkown
HY-RS05481 GLIS2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20743 Gli2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21582 Glis2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27255 Gli2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28100 Glis2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Glis2 NCBI NCBI:84662