2. Gene
  3. Hmgcl - 3-hydroxy-3-methylglutaryl-CoA lyase Gene

Hmgcl - 3-hydroxy-3-methylglutaryl-CoA lyase Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 79238 | Gene type: protein coding

About Hmgcl

Summary

Enables carboxylic acid binding activity; fatty-acyl-CoA binding activity; and hydroxymethylglutaryl-CoA lyase activity. Involved in several processes, including acyl-CoA metabolic process; ketone body biosynthetic process; and liver development. Located in mitochondrion. Human ortholog(s) of this gene implicated in amino acid metabolic disorder. Orthologous to human HMGCL (3-hydroxy-3-methylglutaryl-CoA lyase). [provided by Alliance of Genome Resources, Apr 2022]

Hmgcl Products(1)

mRNA Protein Name
NM_024386.2 NP_077362.1 hydroxymethylglutaryl-CoA lyase, mitochondrial precursor
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables carboxylic acid binding IPI
IPI: Inferred from physical interaction
2573547 RGD
enables fatty-acyl-CoA binding IPI
IPI: Inferred from physical interaction
2573547 RGD
enables hydroxymethylglutaryl-CoA lyase activity IDA
IDA: Inferred from direct assay
2573547 RGD
Biological Process GO Annotation Evidence Reference Source
involved in acyl-CoA metabolic process IDA
IDA: Inferred from direct assay
2573547 RGD
involved in ketone body biosynthetic process IDA
IDA: Inferred from direct assay
2573547 RGD
involved in liver development IEP
IEP: Inferred from expression pattern
13990 RGD
involved in response to fatty acid IEP
IEP: Inferred from expression pattern
10419135 RGD
involved in response to nutrient IEP
IEP: Inferred from expression pattern
5667251 RGD
involved in response to starvation IEP
IEP: Inferred from expression pattern
5667251 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

hydroxymethylglutaryl-CoA lyase, mitochondrial

3-hydroxy-3-methylglutarate-CoA lyase

3-hydroxy-3-methylglutaryl-Coenzyme A lyase

3-hydroxymethyl-3-methylglutaryl-CoA lyase

3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase

HL

HMG-CoA lyase

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS06236 HMGCL Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS20953 Hmgcl Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS27470 Hmgcl Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hmgcl NCBI NCBI:3155