IRX1 - iroquois homeobox 1 Gene

Homo sapiens

Also known as IRX-5; IRXA1

Gene ID: 79192 | Gene type: protein coding

About IRX1

Cytogenetic location: 5p15.33 Genomic coordinates (GRCh38): 5:3,595,832-3,601,403 (from NCBI)

This gene has 1 transcript (splice variant), 186 orthologues and 6 paralogues. Biased expression in kidney (RPKM 2.5), salivary gland (RPKM 1.1) and 4 other tissues.

Summary

This gene encodes a member of the Iroquois homeobox protein family. Homeobox genes in this family are involved in pattern formation in the embryo. The gene product has been identified as a tumor suppressor in gastric (PMID: 21602894, 20440264) and head and neck cancers (PMID: 18559491). A pseudogene of this gene is located on chromosome 13. [provided by RefSeq, Dec 2011]

IRX1 Products(1)

mRNA	Protein	Name
NM_024337.4	NP_077313.3	iroquois-class homeodomain protein IRX-1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	20440264	GOA
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	20440264	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IRX1 Protein Structure

Homeobox_KN

0
100
200
300
400
480 a.a.

Protein Preferred Names

Protein Names

iroquois-class homeodomain protein IRX-1

homeodomain protein IRXA1

Related Diseases

Diseases

Alias

Pulmonary Immaturity

Primary Atelectasis Of Newborn	Primary Atelectasis, In Perinatal Period
Primary Failure To Expand Terminal Respiratory Units	Immature Lungs
Primary Atelectasis	Pulmonary Immaturity Nos
Lung Lobe Hypoplasia, Associated With Short Gestation	Lung Nonexpansion
Premature Lungs	Pulmonary Hypoplasia Associated With Short Gestation
Failure Of Expansion Of Terminal Respiratory Units	Primary Atelectasis Of Fetus Or Newborn
Primary Atelectasis In Perinatal Period

Scoliosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06920	IRX1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	IRX1	VGNC	VGNC:30286
Felis catus	IRX1	VGNC	VGNC:102235
Mus musculus	IRX1	MGD	MGI:1197515
Macaca mulatta	IRX1	VGNC	VGNC:73591
Rattus norvegicus	IRX1	RGD	RGD:1309060

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