ZNF141 - zinc finger protein 141 Gene

Homo sapiens

Also known as D4S90; pHZ-44

Gene ID: 7700 | Gene type: protein coding

About ZNF141

Cytogenetic location: 4p16.3 Genomic coordinates (GRCh38): 4:337,814-384,868 (from NCBI)

This gene has 6 transcripts (splice variants), 5 orthologues, 174 paralogues and is associated with 2 phenotypes. Ubiquitous expression in adrenal (RPKM 3.7), lymph node (RPKM 3.5) and 25 other tissues.

Summary

The protein encoded by this gene is a Zinc Finger Protein that may be a tumor suppressor. Defects in this gene have been associated with autosomal recessive postaxial polydactyly type A. [provided by RefSeq, Jan 2017]

ZNF141 Products(5)

mRNA	Protein	Name
NM_001348277.2	NP_001335206.1	zinc finger protein 141 isoform 2
NM_001348278.2	NP_001335207.1	zinc finger protein 141 isoform 3
NM_001348279.2	NP_001335208.1	zinc finger protein 141 isoform 4
NM_001348280.2	NP_001335209.1	zinc finger protein 141 isoform 5
NM_003441.4	NP_003432.1	zinc finger protein 141 isoform 1

Gene Ontology

Biological Process

Biological Process GO Annotation	Evidence	Reference	Source
involved in limb morphogenesis	IMP IMP: Inferred from mutant phenotype	23160277	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	7649249	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZNF141 Protein Structure

KRAB

zf-H2C2_2

0
100
200
300
400
474 a.a.

Protein Preferred Names

Protein Names

zinc finger protein 141

zinc finger protein 141 (clone pHZ-44)

Related Diseases

Diseases

Alias

Polydactyly, Postaxial, Type A6

PAPA6

Polydactyly, Postaxial A6

Polydactyly, Postaxial, Type A1

Postaxial Polydactyly Type A	Polydactyly, Postaxial
Postaxial Polydactyly	PAPA1
Postaxial Polydactyly, Type A	Papa
Polydactyly, Postaxial, Types A1 And B	Postaxial Polydactyly Type B
Polydactyly Postaxial	Polydactyly, Postaxial A1
Polydactyly, Postaxial B	PAPB
Postaxial Polydactyly, Type A1/B	Polydactyly, Postaxial, Type A
Pyogenic Arthritis, Pyoderma Gangrenosum And Acne	Postaxial Polydactyly, Type B

Polydactyly

Non-Syndromic Polydactyly	Polydactyly, Postaxial
Postaxial Polydactyly	Supernumerary Digit
Extra Digits	Hyperdactyly
Polydactylia	Polydactylism
Supernumerary Digits

Short-Rib Thoracic Dysplasia 14 With Polydactyly

SRTD14

Laurin-Sandrow Syndrome

Sandrow Syndrome	Tetramelic Mirror-Image Polydactyly
Mirror-Image Polydactyly	Mirror Hands And Feet With Nasal Defects
Tmip	LSS
Mip	Mirror Hands And Feets-Nasal Defects Syndrome
Fibula And Ulna, Duplication Of, With Absence Of Tibia And Radius	Miccor Hands And Feet With Nasal Defects
Mipduplication Of Fibuland Ulna With Absence Of Tibia And Radius	Fibula Ulna Duplication Tibia Radius Absence
Laurin Sandrow Syndrome	Duplication Of Fibula And Ulna With Absence Of Tibia And Radius
Segmental Laurin-Sandrow Syndrome	Laurin-Sandrow Syndrome, Segmental

Greig Cephalopolysyndactyly Syndrome

GCPS	Polysyndactyly With Peculiar Skull Shape
Polysyndactyly With Peculiars Skull Shape	Greig Syndrome
Cephalopolysyndactyly Syndrome	Greig Cephalo-Poly-Syndactyly Syndrome
Cephalopolysyndactyly, Greig Syndrome	Aarskog Syndrome

Syndactyly, Type Iv

Syndactyly Type 4	Polysyndactyly, Haas Type
SDTY4	Haas Type Syndactyly
Sd4	Polysyndactyly Type Haas
Syndactyly 4	Polysyndactyly Haas Type
Syndactyly Type Iv

Skin Tag

Fibroepithelial Polyp	Fibroepithelial Polyp Of Skin
Soft Fibroma	Skin Tags
Cutaneous Tag	Gardner Fibroma
Acrochordon	Fibroma Molle

Wolf-Hirschhorn Syndrome

Pitt-Rogers-Danks Syndrome	WHS
Chromosome 4p16.3 Deletion Syndrome	Wittwer Syndrome
4p- Syndrome	Pitt Syndrome
4p Deletion Syndrome	Distal Deletion 4p
Distal Monosomy 4p	Telomeric Deletion 4p
Prds	4p Syndrome
Chromosome 4p Syndrome	Microcephaly, Iugr, Hypertelorism, Ptosis, Iris Coloboma, Hooked Nose, External Ear Dysplasia, Psychomotor Retardation
Wolf Syndrome	Chromosome 4p Deletion Syndrome
Chromosome 4p Monosomy	Del Syndrome
Monosomy 4p	Partial Monosomy 4p
Chromosome 4 Short Arm Deletion

Acrocallosal Syndrome

ACLS	Schinzel Acrocallosal Syndrome
Joubert Syndrome 12	Schinzel Syndrome 1
Acrocallosal Syndrome, Schinzel Type	Hallux Duplication, Postaxial Polydactyly, And Absence Of Corpus Callosum
Acs	Absence Of Corpus Callosum With Unusual Facial Appearance, Mental Deficiency, Duplication Of The Halluces And Polydactyly
Hallux Duplication Postaxial Polydactyly And Absence Of Corpus Callosum	JBTS12
Acrocallosal Syndrome

Pallister-Hall Syndrome

PHS	Hypothalamic Hamartomas
Hypothalamic Hamartoblastoma, Hypopituitarism, Imperforate Anus, And Postaxial Polydactyly	Hypothalamic Hamartoblastoma Syndrome
Hamartoma Of The Hypothalamus	Pallister Hall Syndrome
Hall-Pallister Syndrome	Hypothalamic Hamartoblastoma Hypopituitarism Imperforate Anus And Postaxial Polydactyly
Hamartoma, Hypothalamic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16101	ZNF141 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

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