Pank2 - pantothenate kinase 2 Gene

Mus musculus

Also known as hPanK2; 4933409I19Rik

Gene ID: 74450 | Gene type: protein coding

About Pank2

Summary

Enables pantothenate kinase activity. Acts upstream of or within several processes, including coenzyme A biosynthetic process; mitochondrion morphogenesis; and spermatid development. Located in cytosol and mitochondrion. Human ortholog(s) of this gene implicated in pantothenate kinase-associated neurodegeneration. Orthologous to human PANK2 (pantothenate kinase 2). [provided by Alliance of Genome Resources, Apr 2022]

Pank2 Products(10)

mRNA	Protein	Name
NM_001355679.1	NP_001342608.1	pantothenate kinase 2, mitochondrial isoform b
NM_001355681.1	NP_001342610.1	pantothenate kinase 2, mitochondrial isoform c
NM_001355682.1	NP_001342611.1	pantothenate kinase 2, mitochondrial isoform c
NM_001355683.1	NP_001342612.1	pantothenate kinase 2, mitochondrial isoform d
NM_153501.3	NP_705721.3	pantothenate kinase 2, mitochondrial isoform a
NM_001355679.1	NP_001342608.1	pantothenate kinase 2, mitochondrial isoform b
NM_001355681.1	NP_001342610.1	pantothenate kinase 2, mitochondrial isoform c
NM_001355682.1	NP_001342611.1	pantothenate kinase 2, mitochondrial isoform c
NM_001355683.1	NP_001342612.1	pantothenate kinase 2, mitochondrial isoform d
NM_153501.3	NP_705721.3	pantothenate kinase 2, mitochondrial isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables pantothenate kinase activity	IDA IDA: Inferred from direct assay	17825826	MGI
enables pantothenate kinase activity	IGI IGI: Inferred from genetic interaction	11479594	MGI
enables pantothenate kinase activity	IMP IMP: Inferred from mutant phenotype	17379144	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within aerobic respiration	IMP IMP: Inferred from mutant phenotype	22983956	MGI
involved in coenzyme A biosynthetic process	IGI IGI: Inferred from genetic interaction	22815849	MGI
acts upstream of or within coenzyme A biosynthetic process	IMP IMP: Inferred from mutant phenotype	22815849	MGI
involved in coenzyme A biosynthetic process	IMP IMP: Inferred from mutant phenotype	24316510	MGI
acts upstream of or within mitochondrion organization	IMP IMP: Inferred from mutant phenotype	22983956	MGI
acts upstream of or within regulation of mitochondrial membrane potential	IMP IMP: Inferred from mutant phenotype	22983956	MGI
acts upstream of or within spermatid development	IMP IMP: Inferred from mutant phenotype	15525657	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytosol	IDA IDA: Inferred from direct assay	17825826	MGI
is active in mitochondrial intermembrane space	IDA IDA: Inferred from direct assay	22983956	MGI
NOT located in mitochondrion	IDA IDA: Inferred from direct assay	17825826	MGI
located in mitochondrion	IMP IMP: Inferred from mutant phenotype	22983956	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

pantothenate kinase 2, mitochondrial

pantothenate kinase 2 (Hallervorden-Spatz syndrome)

pantothenic acid kinase 2

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-124634	PZ-2891	Modulator	99.68%	Unkown
HY-RS10017	PANK2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS21012	Pank2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS27529	Pank2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pank2	NCBI	NCBI:80025

Name
Email *

	Sorry, but the email address you supplied was invalid.