Appl1 - adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 Gene

Mus musculus

Also known as DIP13; 2900057D21Rik; 7330406P05Rik

Gene ID: 72993 | Gene type: protein coding

About Appl1

Summary

Predicted to enable several functions, including beta-tubulin binding activity; phospholipid binding activity; and protein homodimerization activity. Involved in several processes, including cellular response to hepatocyte growth factor stimulus; positive regulation of cytokine production involved in inflammatory response; and regulation of vesicle-mediated transport. Located in cytoplasmic vesicle and ruffle. Is expressed in several structures, including liver; muscle tissue; spleen; stomach; and testis. Human ortholog(s) of this gene implicated in maturity-onset diabetes of the young type 14. Orthologous to human APPL1 (adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1). [provided by Alliance of Genome Resources, Apr 2022]

Appl1 Products(1)

mRNA	Protein	Name
NM_145221.3	NP_660256.1	DCC-interacting protein 13-alpha

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	19661063	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to hepatocyte growth factor stimulus	IMP IMP: Inferred from mutant phenotype	26445298	MGI
involved in negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis	IMP IMP: Inferred from mutant phenotype	25568335	MGI
involved in positive regulation of cytokine production involved in inflammatory response	IMP IMP: Inferred from mutant phenotype	25328665	MGI
involved in positive regulation of macropinocytosis	IMP IMP: Inferred from mutant phenotype	27219021	MGI
involved in regulation of fibroblast migration	IMP IMP: Inferred from mutant phenotype	26445298	MGI
involved in regulation of innate immune response	IMP IMP: Inferred from mutant phenotype	27219021	MGI
involved in regulation of toll-like receptor 4 signaling pathway	IMP IMP: Inferred from mutant phenotype	27219021	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in early endosome	IDA IDA: Inferred from direct assay	21849472	MGI
located in early phagosome	IDA IDA: Inferred from direct assay	25568335	MGI
located in endosome	IDA IDA: Inferred from direct assay	25568335	MGI
located in macropinosome	IDA IDA: Inferred from direct assay	27219021	MGI
located in ruffle	IDA IDA: Inferred from direct assay	25568335	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

DCC-interacting protein 13-alpha

DIP13 alpha	adapter protein containing PH domain, PTB domain and leucine zipper motif 1
adaptor protein APPL like	dip13-alpha

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00867	APPL1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS20366	Appl1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS26876	Appl1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Appl1	NCBI	NCBI:26060

Name
Email *

	Sorry, but the email address you supplied was invalid.