2. Gene
  3. Tppp - tubulin polymerization promoting protein Gene

Tppp - tubulin polymerization promoting protein Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as TPPP/p25; 2900041A09Rik

Gene ID: 72948 | Gene type: protein coding

About Tppp

Summary

Predicted to enable several functions, including GTPase activity; magnesium ion binding activity; and protein homodimerization activity. Involved in microtubule polymerization; nervous system development; and positive regulation of myelination. Located in cytoplasm and nucleus. Colocalizes with microtubule. Is expressed in several structures, including central nervous system; genitourinary system; gut; hemolymphoid system gland; and nasal cavity epithelium. Orthologous to human TPPP (tubulin polymerization promoting protein). [provided by Alliance of Genome Resources, Apr 2022]

Tppp Products(1)

mRNA Protein Name
NM_182839.2 NP_878259.1 tubulin polymerization-promoting protein
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
involved in microtubule polymerization IDA
IDA: Inferred from direct assay
18028908 MGI
involved in myelin assembly IMP
IMP: Inferred from mutant phenotype
31522887 MGI
involved in oligodendrocyte development IMP
IMP: Inferred from mutant phenotype
31522887 MGI
involved in oligodendrocyte differentiation IMP
IMP: Inferred from mutant phenotype
31522887 MGI
involved in positive regulation of myelination IMP
IMP: Inferred from mutant phenotype
31522887 MGI
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
18028908 MGI
colocalizes with microtubule IDA
IDA: Inferred from direct assay
18028908 MGI
located in nucleus IDA
IDA: Inferred from direct assay
18028908 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

tubulin polymerization-promoting protein

25 kDa brain-specific protein

brain-specific protein p25 alpha

p25-alpha

Related Agents

Pre-clinical Phase
Bioactive Molecules (7)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-176305S Neurofilament, U-15N / Unkown
HY-RS14944 TPPP Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14945 TPPP3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19391 Tppp Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19487 Tppp3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25883 Tppp Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25981 Tppp3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tppp NCBI NCBI:11076