Pgam5 - phosphoglycerate mutase family member 5 Gene

Mus musculus

Also known as 2610528A17Rik

Gene ID: 72542 | Gene type: protein coding

About Pgam5

Summary

Predicted to enable GTPase activator activity and protein serine/threonine Phosphatase activity. Involved in necroptotic process and negative regulation of cold-induced thermogenesis. Predicted to be located in mitochondrial outer membrane. Predicted to be integral component of membrane. Predicted to be active in mitochondrion. Orthologous to human PGAM5 (PGAM family member 5, mitochondrial serine/threonine protein Phosphatase). [provided by Alliance of Genome Resources, Apr 2022]

Pgam5 Products(2)

mRNA	Protein	Name
NM_001163538.1	NP_001157010.1	serine/threonine-protein phosphatase PGAM5, mitochondrial isoform 1
NM_028273.3	NP_082549.2	serine/threonine-protein phosphatase PGAM5, mitochondrial isoform 2

Gene Ontology

Biological Process

Biological Process GO Annotation	Evidence	Reference	Source
involved in necroptotic process	IMP IMP: Inferred from mutant phenotype	22265414	MGI
involved in negative regulation of cold-induced thermogenesis	IMP IMP: Inferred from mutant phenotype	27077115	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

serine/threonine-protein phosphatase PGAM5, mitochondrial

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-139598	LFHP-1c	Inhibitor	98.01%	Unkown
HY-RS10376	PGAM5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17555	Pgam5 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24013	Pgam5 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pgam5	NCBI	NCBI:192111

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