2. Gene
  3. Suz12 - SUZ12 polycomb repressive complex 2 subunit Gene

Suz12 - SUZ12 polycomb repressive complex 2 subunit Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 688041 | Gene type: protein coding

About Suz12

Summary

Predicted to enable several functions, including nucleic acid binding activity; promoter-specific chromatin binding activity; and transcription corepressor binding activity. Involved in several processes, including histone H3-K27 trimethylation; negative regulation of macromolecule metabolic process; and response to retinoic acid. Predicted to be located in nuclear body; nucleolus; and sex chromatin. Predicted to be part of nucleus; protein-DNA complex; and ribonucleoprotein complex. Biomarker of spina bifida. Orthologous to human SUZ12 (SUZ12 polycomb repressive complex 2 subunit). [provided by Alliance of Genome Resources, Apr 2022]

Suz12 Products(3)

mRNA Protein Name
XM_039087644.1 XP_038943572.1 polycomb protein SUZ12 isoform X1
XM_039087645.1 XP_038943573.1 polycomb protein SUZ12 isoform X2
XM_039087646.1 XP_038943574.1 polycomb protein SUZ12 isoform X3
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
23879974 RGD
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of chemokine production IMP
IMP: Inferred from mutant phenotype
23192652 RGD
involved in negative regulation of epithelial cell proliferation IMP
IMP: Inferred from mutant phenotype
23192652 RGD
involved in negative regulation of protein modification process IMP
IMP: Inferred from mutant phenotype
23192652 RGD
involved in protein modification process IMP
IMP: Inferred from mutant phenotype
23192652 RGD
involved in response to retinoic acid IEP
IEP: Inferred from expression pattern
20515739 RGD
involved in spinal cord development IEP
IEP: Inferred from expression pattern
20515739 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

polycomb protein SUZ12

Related Agents

Pre-clinical Phase
Bioactive Molecules (10)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-101512 A-395 Inhibitor 99.12% Unkown
HY-W014099 Boc-NH-C4-acid 99.85% Unkown
HY-158239 MS181 Inhibitor 98.36% Unkown
HY-157164 PROTAC EZH2 Degrader-2 Degrader 99.78% Unkown
HY-130638 (S,R,S)-AHPC-O-Ph-PEG1-NH-Boc / Unkown
HY-130637 Boc-NH-PEG1-Ph-O-CH2COOH / Unkown
HY-174372 EZH2-IN-23 Inhibitor / Unkown
HY-RS14053 SUZ12 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS17149 Suz12 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS23598 Suz12 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Suz12 NCBI NCBI:23512