2. Gene
  3. Myo3a - myosin IIIA Gene

Myo3a - myosin IIIA Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as 9030416P08Rik

Gene ID: 667663 | Gene type: protein coding

About Myo3a

Summary

Enables actin filament binding activity; microfilament motor activity; and protein serine/threonine kinase activity. Involved in auditory receptor cell stereocilium organization; cochlea morphogenesis; and sensory perception of sound. Acts upstream of or within several processes, including positive regulation of filopodium assembly; protein phosphorylation; and regulation of actin filament length. Located in filopodium tip; photoreceptor inner segment; and stereocilium tip. Is expressed in cochlea and metanephros. Used to study autosomal recessive nonsyndromic deafness 30. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 30. Orthologous to human MYO3A (Myosin IIIA). [provided by Alliance of Genome Resources, Apr 2022]

Myo3a Products(1)

mRNA Protein Name
NM_148413.3 NP_680779.3 myosin-IIIa
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables actin filament binding IDA
IDA: Inferred from direct assay
22264607 MGI
enables microfilament motor activity IDA
IDA: Inferred from direct assay
22264607 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
26754646 MGI
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
21895655 MGI
Biological Process GO Annotation Evidence Reference Source
involved in auditory receptor cell stereocilium organization IGI
IGI: Inferred from genetic interaction
26754646 MGI
involved in auditory receptor cell stereocilium organization IMP
IMP: Inferred from mutant phenotype
26754646 MGI
involved in cochlea morphogenesis IMP
IMP: Inferred from mutant phenotype
26754646 MGI
acts upstream of or within inner ear development IMP
IMP: Inferred from mutant phenotype
21165622 MGI
acts upstream of or within peptidyl-serine phosphorylation IDA
IDA: Inferred from direct assay
21895655 MGI
acts upstream of or within peptidyl-threonine phosphorylation IDA
IDA: Inferred from direct assay
21895655 MGI
acts upstream of or within positive regulation of filopodium assembly IGI
IGI: Inferred from genetic interaction
22264607 MGI
acts upstream of or within protein autophosphorylation IDA
IDA: Inferred from direct assay
21895655 MGI
involved in regulation of actin filament length IGI
IGI: Inferred from genetic interaction
26754646 MGI
involved in regulation of actin filament length IMP
IMP: Inferred from mutant phenotype
26754646 MGI
involved in sensory perception of sound IGI
IGI: Inferred from genetic interaction
26754646 MGI
acts upstream of or within sensory perception of sound IMP
IMP: Inferred from mutant phenotype
21165622 MGI
involved in sensory perception of sound IMP
IMP: Inferred from mutant phenotype
26754646 MGI
Cellular Component GO Annotation Evidence Reference Source
located in filopodium tip IDA
IDA: Inferred from direct assay
22264607 MGI
located in photoreceptor inner segment IDA
IDA: Inferred from direct assay
19332056 MGI
is active in stereocilium tip EXP
EXP: Inferred from Experiment
26754646 MGI
located in stereocilium tip IDA
IDA: Inferred from direct assay
21165622 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

myosin-IIIa

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS08944 MYO3A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22663 Myo3a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29177 Myo3a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Myo3a NCBI NCBI:53904