Kcnd2 - potassium voltage-gated channel subfamily D member 2 Gene

Rattus norvegicus

Also known as RK5; Kv4.2; Shal1

Gene ID: 65180 | Gene type: protein coding

About Kcnd2

Summary

Enables A-type (transient outward) Potassium Channel activity and voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential. Involved in several processes, including cellular response to hypoxia; cellular response to mechanical stimulus; and potassium ion transmembrane transport. Located in several cellular components, including T-tubule; neuronal cell body membrane; and perinuclear endoplasmic reticulum. Is integral component of plasma membrane. Part of voltage-gated Potassium Channel complex. Is active in glutamatergic synapse. Is integral component of postsynaptic membrane. Orthologous to human KCND2 (potassium voltage-gated channel subfamily D member 2). [provided by Alliance of Genome Resources, Apr 2022]

Kcnd2 Products(1)

mRNA	Protein	Name
NM_031730.2	NP_113918.2	potassium voltage-gated channel subfamily D member 2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables A-type (transient outward) potassium channel activity	IDA IDA: Inferred from direct assay	1722463	RGD
enables A-type (transient outward) potassium channel activity	IMP IMP: Inferred from mutant phenotype	16123112	RGD
enables monoatomic ion channel activity	IDA IDA: Inferred from direct assay	10325948	RGD
enables potassium channel activity	IDA IDA: Inferred from direct assay	10325948	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	11805342	RGD
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	14980206	RGD
enables voltage-gated potassium channel activity	IDA IDA: Inferred from direct assay	1722463	RGD
enables voltage-gated potassium channel activity	IMP IMP: Inferred from mutant phenotype	16123112	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in action potential	IMP IMP: Inferred from mutant phenotype	16141270	RGD
involved in cardiac muscle cell action potential	IMP IMP: Inferred from mutant phenotype	9058605	RGD
involved in cellular response to hypoxia	IDA IDA: Inferred from direct assay	25352783	RGD
involved in cellular response to mechanical stimulus	IEP IEP: Inferred from expression pattern	17293496	RGD
involved in cellular response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	17293496	RGD
involved in potassium ion transmembrane transport	IDA IDA: Inferred from direct assay	1722463	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in T-tubule	IDA IDA: Inferred from direct assay	10860776	RGD
located in caveola	IDA IDA: Inferred from direct assay	20224290	RGD
located in dendrite	IDA IDA: Inferred from direct assay	15356203	RGD
located in dendritic spine	IDA IDA: Inferred from direct assay	9070739	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	17582333	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	15736227	RGD
located in neuronal cell body membrane	IDA IDA: Inferred from direct assay	9070739	RGD
located in perinuclear endoplasmic reticulum	IDA IDA: Inferred from direct assay	12967630	RGD
located in plasma membrane	IDA IDA: Inferred from direct assay	1722463	RGD
located in plasma membrane	IMP IMP: Inferred from mutant phenotype	1722463	RGD
located in plasma membrane raft	IDA IDA: Inferred from direct assay	24793047	RGD
is active in postsynaptic membrane	IDA IDA: Inferred from direct assay	17582333	RGD
located in postsynaptic membrane	IDA IDA: Inferred from direct assay	9070739	RGD
part of potassium channel complex	IDA IDA: Inferred from direct assay	14980206	RGD
located in sarcolemma	IDA IDA: Inferred from direct assay	10860776	RGD
part of voltage-gated potassium channel complex	IDA IDA: Inferred from direct assay	15356203	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

potassium voltage-gated channel subfamily D member 2

potassium channel, voltage-gated Shal-related subfamily D, member 2	potassium voltage gated channel, Shal-related family, member 2
potassium voltage-gated channel, Shal-related subfamily, member 2	voltage-gated potassium channel subunit Kv4.2

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07113	KCND2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS21609	Kcnd2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS28127	Kcnd2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Kcnd2	NCBI	NCBI:3751

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