Taok2 - TAO kinase 2 Gene

Rattus norvegicus

Also known as Tao2

Gene ID: 64666 | Gene type: protein coding

About Taok2

Summary

Enables ATP binding activity and MAP kinase kinase kinase activity. Involved in MAPK cascade; basal dendrite arborization; and regulation of synaptic membrane adhesion. Is active in glutamatergic synapse. Orthologous to human TAOK2 (TAO kinase 2). [provided by Alliance of Genome Resources, Apr 2022]

Taok2 Products(1)

mRNA	Protein	Name
NM_022702.1	NP_073193.1	serine/threonine-protein kinase TAO2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATP binding	IDA IDA: Inferred from direct assay	15458637	RGD
enables MAP kinase kinase kinase activity	IDA IDA: Inferred from direct assay	10497253	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in MAPK cascade	IDA IDA: Inferred from direct assay	10497253	RGD
involved in basal dendrite arborization	IGI IGI: Inferred from genetic interaction	22683681	RGD
involved in basal dendrite morphogenesis	IMP IMP: Inferred from mutant phenotype	22683681	RGD
involved in regulation of postsynapse organization	IDA IDA: Inferred from direct assay	28065648	RGD
involved in regulation of postsynapse organization	IMP IMP: Inferred from mutant phenotype	28065648	RGD
involved in regulation of synaptic membrane adhesion	IDA IDA: Inferred from direct assay	17988630	RGD
involved in regulation of synaptic membrane adhesion	IEP IEP: Inferred from expression pattern	17988630	RGD
involved in regulation of synaptic membrane adhesion	IMP IMP: Inferred from mutant phenotype	17988630	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	17988630	RGD
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	17988630	RGD
is active in postsynapse	IDA IDA: Inferred from direct assay	28065648	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

serine/threonine-protein kinase TAO2

serine-threonine kinase

thousand and one amino acid protein 2

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-100491	H3B-6527	Inhibitor	≥98.0%	Phase 1

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15141	Staurosporine		99.98%	Unkown
HY-122232	SW083688	Inhibitor	/	Unkown
HY-RS14199	TAOK2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20110	Taok2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26614	Taok2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Taok2	NCBI	NCBI:9344

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