2. Gene
  3. Mthfd1 - methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 Gene

Mthfd1 - methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 64300 | Gene type: protein coding

About Mthfd1

Summary

Predicted to enable formate-tetrahydrofolate Ligase activity; methenyltetrahydrofolate cyclohydrolase activity; and methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity. Involved in nucleotide metabolic process; one-carbon metabolic process; and response to nitrogen dioxide. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in several diseases, including Down syndrome; cleft lip; developmental cardiac valvular defect; neural tube defect (multiple); and tetralogy of Fallot. Orthologous to human MTHFD1 (methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1). [provided by Alliance of Genome Resources, Apr 2022]

Mthfd1 Products(1)

mRNA Protein Name
NM_022508.2 NP_071953.2 C-1-tetrahydrofolate synthase, cytoplasmic
Gene Ontology
  • Biological Process
Biological Process GO Annotation Evidence Reference Source
involved in one-carbon metabolic process IEP
IEP: Inferred from expression pattern
14597174 RGD
involved in response to nitrogen dioxide IEP
IEP: Inferred from expression pattern
3264158 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

C-1-tetrahydrofolate synthase, cytoplasmic

C1-THF synthase

C1-tetrahydrofolate synthase

methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase

methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetr

Related Agents

Pre-clinical Phase
Bioactive Molecules (12)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-130251 DS18561882 99.87% Unkown
HY-101943 LY 345899 ≥98.0% Unkown
HY-155950 TH9619 99.33% Unkown
HY-131943 DS44960156 99.36% Unkown
HY-155219 TH9028 Inhibitor / Unkown
HY-172910 MTHFD2-IN-6 Inhibitor / Unkown
HY-RS08774 MTHFD1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS08775 MTHFD1L Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS17098 Mthfd1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS20214 Mthfd1l Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS23542 Mthfd1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS26720 Mthfd1l Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mthfd1 NCBI NCBI:4522